Scoliosis and dental occlusion: a review of the literature
© Saccucci et al; licensee BioMed Central Ltd. 2011
Received: 21 January 2011
Accepted: 29 July 2011
Published: 29 July 2011
Idiopathic scoliosis is a deformity without clear etiology. It is unclear wether there is an association between malocclusion and scoliosis. Several types of occlusion were described in subjects with scoliosis, mostly case-reports.
The aim of this review was to evaluate the type of occluslins more prevalent in subjects with scoliosis
All randomised and controlled clinical trials identified from the Cochrane Oral Health Group Trials Register, a MEDLINE search using the Mesh term scoliosis, malocclusion, and relevant free text words, and the bibliographies of papers and review articles which reported the outcome of orthodontic treatment in subjects with scoliosis that were published as abstracts or papers between 1970 and 2010.
All randomised and controlled clinical trials published as full papers or abstracts which reported quantitative data on the outcomes malocclusion in subjects with scoliosis.
Data collection and analysis
Data were extracted without blinding to the authors, age of patients or type of occlusion.
Using the search strategy eleven observational longitudinal studies were identified. No randomized clinical trials were recorded. Twenty-three cross-sectional studies were recorderd, and the others studies were reviews, editorials, case-reports, or opinions. The clinical trials were often not controlled and were about the cephalometric evaluation after treatment with the modified Milwuakee brace, followed by the orthodontic treatment of the class II relationship with a functional appliance. Clinical trials also included the study of the associations between scoliosis and unilateral crossbite, in children with asymmetry of the upper cervical spine. This association was also investigated in rats, pigs and rabbits in clinical trials. The other associations between scoliosis and occlusion seems to be based only on cross-sectional studies, case-reports, opinions.
Based on selected studies, this review concludes that there is plausible evidence for an increased prevalence of unilateral Angle Class II malocclusions associated with scoliosis, and an increased risk of lateral crossbite, midline deviation in children affected by scoliosis. Also, documentation of associations between reduced range of lateral movements and scoliosis seem convincing. Data are also mentioned about the association between plagiocephaly and scoliosis.
Idiopathic scoliosis is a deformity without clear etiology. Depending on the age of presentation it has been classified into 3 types: infantile (presenting from birth to 3 years), juvenile (presenting from 3 to 10 years) and adolescent (presenting from 10 years to skeletal maturity) . Eighty percent or more of idiopathic scoliosis is of the adolescent variety . The most infantile curves present in the first six months of life are left thoracic apex, and males are more frequently affected, whereas the most common juvenile curves are right thoracic apex and females are more frequently affected, as in the adolescent group 
In the case of the most common form of scoliosis, adolescent idiopathic scoliosis, there is no clear causal agent and it is generally believed to be multifactorial. Genetics are believed to play a role . There is often a positive family history but the pattern of inherited susceptibility is not clear . Adolescent idiopathic scoliosis is defined as a spinal curve or curves of ten degrees or more in about 2.5% of most populations . However, in only about 0.25% the curve does progress to the point that treatment is warranted .
Some hypothesis exists in the possible underlying pathophysiological mechanism leading to this deformity. The major types of non-idiopathic scoliosis are congenital scoliosis due to malformation or faulty segmentation of the vertebrae and neuromuscular scoliosis due to muscular imbalance.
The scoliosis can be due to malformation or faulty segmentation of the vertebrae or can be due to muscular imbalance .
Different factors have been suggested as causal. Among these, the following should be highlighted: deviation from the standard growth pattern, neuromuscular or conjunctive tissue alterations, asymmetric growth of the limbs and trunk, alterations in the sagittal configuration of the spine; and environmental factors [6, 7].
Non-congenital scoliosis has many etiologies. The hereditary musculoskeletal disorders, such as osteogenesis imperfecta, Marfan syndrome, Stickler syndrome, Ehlers-Danlos syndrome, and the muscular dystrophies, can each include scoliosis as a manifestation. Neuromuscular diseases, such as cerebral palsy and myelomeningocele, are associated with the development of scoliosis secondary to muscle imbalance. Paralytic disorders resulting from polio or spinal trauma may lead to a progressive scoliosis .
In dentistry, the study of the relationship between occlusal problems and the spine are of increasing interest. This is the result of a greater incidence of pain in the muscles of the neck, trunk, the upper and lower limbs, and in the temporomandibular joints (TMJ) of patients with occlusal dysfunction . There are several conditions that impede normal trunk alignment in the frontal plane, and it appear interesting to investigate whether such conditions also affect dental occlusion.
Since '70 Fonder,  a dentist, presented case history evidence to evidence a causal relationship between occlusion and scoliosis, and vice-versa, as he underlined the relationship of dental malocclusions to various skeletal problems such as scoliosis, kyphosis, and other postural defects. He showed full spine radiographs, both lateral and frontal, before and after dental treatment for malocclusions in three patients. Case I exhibited noticeable scoliosis and other "defects of posture" notably excess thoracic kyphosis, in the pre-treatment films. Following a course of dental treatment for a bite defect, the post-treatment radiograph revealed a non scoliotic spine with normal lateral and antero-posterior curvatures. Case 2 was similar except that the scoliosis and kyphosis before the treatment were less marked, described as being only a case of bad posture. After orthodontic treatment for deep overbite related to posterior malocclusion, the post-treatment x-ray revealed a normal appearing spine. Fonder described the patient as having greatly improved posture. In the third case, a woman with similar abnormal scoliotic and kyphotic curves in the spine also complained of general ill health with headaches, backaches and limited range of motion of the back. Following prosthetic and other standard dental work, all of these symptoms were said to disappear and the spine on post-treatment x-ray examination appeared more normal.
Principal papers showed in this review.
McMaster J (1965)
3 clinical cases
Casual relationship between malocclusion and scoliosis, and viceversa
After orthodontic treatment, the author observed the improvment of posture
Rock and Baker (1972). Reference 
Class II due to the weared cast
14 years old
to recommend the use of a removable appliance to prevent the malocclusion before the surgeon operation and during the period of the wearing the cast.
Dayan et al. (1977). Reference 
Transversal Case-control study
To compare facial morphology of children affected with scoliosis and treated with brace, with health children
5-19 years (mean 10 years)
Children treated with braces (for their scoliosis) showed all vertical measurements of face significantly lower than the control group, and more protruted maxillary and mandibular bases
Hotchcock HP (1969).
Observational study on prevalence
Plagiocephaly in subjects with scoliosis
The study suggested the existence of an association between infantile scoliosis and plagiocephaly
Ben-Bassat Y et al. (2006)
Observational study on prevalence
Prevalence of scoliosis in patients with ereditated malocclusion
The detection of hereditary orthodontic anomalies in young children allows the identification of a group of children who have a high risk of developing scoliosis in later years.
Segatto et al. (2008)
Malocclusion in subjects with idiopathic scoliosis
98 subjects with scoliosis and 705 controls
6.2 - 25.3; mean age 13.9 +/- 3.5
a significant higher prevalence of unilateral Angle class II (asymmetric class II malocclusion) was evident among the patients with scoliosis (21.9%) compared with the control group (8.5%). The differences between the two groups in the prevalence of the midline deviation were statistically significant both in the upper and the lower dental arches.
Lippold C et al. (2003).
To evaluate the differences in occlusion
28 with scoliosis and 68 health children
Mean age 14.7 +/- 2.3
In the group of adolescents with scoliosis, infacts, the unilateral Angle class II relationship showed a significant higher prevalence respect to the control group
Lippold et al. (2007)
53 adult patients with Class II and Class III, but withut scoliosis
24.6 +/- 9
an orthopedic examination can be considered for patients undergoing an orthodontic-operative therapy, also when they don't show scoliosis.
Korbmacher H. et al. (2007).
Prevalence of scoliosis in subjects with jaw deformity
85 patients with jaw deformity and 20 control subjects
Of the 85 patients with jaw deformity, 23 (27.1%) had a Cobb angle exceeding 10°. None of the control group had scoliosis exceeding 10°.
Pedrotti et al. (2007).
To assess the congruence of the laterality of cross-bite and the orthopaedic asymmetry
55 children with unilateral cross-bite, and 55 children with asymmetric cervical spine (and no cross-bite)
among the children who revealed an asymmetric upper cervical spine, the unilateral crossbite was not necessarily combined with a pathological orthopaedic variable,
Lippold et al. (2000)
A prevalence stuydy
Prevalence of bilateral crossbite in subjects with scoliosis
an incidence of scoliotic attitudes of 9.5%, with a statistically significant relationship among that disorders of posture, and the presence of ogival palate with bilateral crossbite
Azuma Y et al. (1999);
D'Attilio M et al. (2005);
Poikela A et al. (1997);
Nerder PH et al. (1999).
The appearence of scoliosis after an imbalance of occlusion
these experimental studies revealed a high level of asymmetry in craniofacial structures, temporomandibular structures and muscle functions after an experimentally induced crossbite
Our primary objective was to systematically review the literature to determine the incidence of malocclusion in adult and adolescents with scoliosis.
We did not consider other postural orthopaedic problems since scoliosis is a well defined pathology in literature.
Assess the clinical consequences for the malocclusion, after the treatment of scoliosis (clinical symptoms).
Assess the clinical consequences for the scoliosis, after the orthodontic treatment (clinical complications and symptoms associated with scoliosis, and severity of complications and symptoms among patients).
Criteria for considering studies for this review
Types of studies
We looked for randomized clinical trials (RCTs), cohort and case-control studies, and case reports.
Types of patients
We included adolescent subjects with malocclusion and scoliosis. For our secondary objective we included patients if they were children/adolescents treated for their scoliosis or malocclusion.
Type of studies
We included studies that reported incidence and desciption of malocclusion associated with scoliosis.
Types of outcomes
Our primary and first secondary outcome of interest was incidence and description of malocclusion in subjects with scoliosis.
Our secondary outcomes of interest were the clinical consequences associated with treatments of malocclusions or scoliosis.
Electronic searches and data retrieval
We searched MEDLINE and EMBASE without language restrictions in September 2010. We also manually searched reference lists from recent review articles. All randomised and controlled clinical trials identified from the Cochrane Oral Health Group Trials Register, a MEDLINE search using the Mesh term scoliosis, malocclusion, and relevant free text words, handsearching the British, European and American journals of orthodontics and Angle Orthodontist, and the bibliographies of papers and review articles which reported the outcome of orthodontic treatment in subjects with scoliosis that were published as abstracts or papers between 1970 and 2010.
Study selection and Data Extractiones of interventions
Two reviewers (ST and MS) independently reviewed the abstracts for potential eligibility and subsequently full text publications for eligibility. Disagreements were resolved by discussion.
We extracted a number of variables on study design and methodological characteristics, patient and intervention characteristics, and outcomes from all eligible studies (see Table 1). Data extraction was done independently by two reviewers (ST and MS) and disagreements were resolved by discussion.
Methodological Quality Assessment
No Randomized clinical trials were recorded for this argument.
For the observational longitudinal studies we noted the presence of control groups only in a few studies. The great part of transversal studies showed a control group.
Using the search strategy eleven observational longitudinal studies were identified. No randomized clinical trials were recorded. Twenty-three cross-sectional studies were recorderd, and the others studies was reviews, editorials, case-reports, or opinions. The clinical trials were often not controlled and were about the cephalometric evaluation after treatment with the modified Milwuakee brace, followed by the orthodontic treatment of the class II relationship with a functional appliance. Clinical trials also included the study of the associations between scoliosis and unilateral crossbite, in children with asymmetry of the upper cervical spine. This association was also investigated in rats, pigs and rabbits in clinical trials. The other associations between scoliosis and occlusion seems to be based only on cross-sectional studies, case-reports, opinions.
Scoliosis and Plagiocephaly
In literature, the association between plagyocephaly and scoliosis was observed during '80 decade in premature infants. The existence of an association is based on clinical case-reports, opinins and cross-sectional studies.
The association between these two conditions has been explained by the nature of plagiocephaly, that is a plastic deformation of the skull. It was hypothesized that when an immobile infant habitually lies towards one side (the case of premature babies) the action of gravity on the plastic skull could cause the uppermost side of the face and head to flow backwards and become recessed, while the lower ear is pushed forwards producing the commonly associated contralateral "bat ear". Associated with this immobility, plagiocephaly, however, rarely persists and once the child becomes mobile, it usually resolves by the age of six years. The scoliosis in these infants was rarely noted at birth but, like the plagiocephaly, developed within the first six months of life in 70% of subjects. In the cited sample, the convex side of the curve corresponded with the recessed side of the head in all except four infants with resolving curves. This close association between the presence, time of presentation and side of the two deformities (both plagiocephaly and infantile idiopathic scoliosis) suggested a possible common pathogenesis.
The Milwuakee brace and malocclusion
A lot of studies made on 60' and 70' years on the use of the original Milwuakee brace in scoliosis therapy demonstrated the damageable effects on teeth occlusion.
About this argument, longitudinal clinical trials were recorded, in addition to clinical cases and observational studies.
Scoliosis and Angle class II molar relationship (unilateral class II malocclusion)
This relationship was investigated mostly through case-control studies and clinical case reports. Among the orthodontic problems associated with scoliosis, attention was given to hereditary orthodontic anomalies (class III, crowding, ogival palate). Hereditary orthodontic anomalies were found at a significant level in a group of 202 adolescent patients diagnosed with idiopathic scoliosis, with a Cobb angle from 20° to 50°,  compared with a matched control health group, while acquired orthodontic anomalies occurred in both groups at about the same rate of frequency, suggesting that the detection of hereditary orthodontic anomalies in young children allows the identification of a group of children who have a high risk of developing scoliosis in later years.
In 2006, the occlusions (Figure 1 2, 3, 4 and 5) of patients with idiopathic scoliosis were clinically examined in a group of 96 consecutive orthopedic patients with idiopathic scoliosis (79 females and 17 males: mean age, 13.9 y; SD: 3.5 y; range, 6.2-25.3 y) . Occlusal features of a random group of 705 children served as the control. In the considered sample, the interarch relationships in the antero-posterior dimension (Angle classification) were similar in the 2 groups for the frequency distributions for normocclusion and Class I malocclusion, but they were significantly different when concerned the Angle class II malocclusion (Figure 2, 3 and 5).
The distribution of the Angle class II malocclusion was significantly different in the scoliotic patients respect to the orthopedic health group.
Specifically, taking in consideration the group of subjects with Class II malocclusion, (Figure 2) with a high overjet (Figure 3), a significant higher prevalence of unilateral Angle class II (asymmetric class II malocclusion) was evident among the patients with scoliosis (21.9%) compared with the control group (8.5%), indicating that the asymmetry in the antero-posterior relationships seems a clinical sign associated with scoliosis.
In particular, while the frequency of asymmetrical molar relationships was identical in the scoliosis and the control groups, great differences in the frequency of asymmetrical canine relationships were encountered; the scoliosis patients were more asymmetric in this regard. In addition, in the same sample, the prevalence of upper midline deviation (Figure 4) (this is a clear clinical sign of occlusal asymmetry) was 21% in the group of scoliosis and 9.5% in the control group; at the same time, the prevalence of lower midline deviation was 53.7% in the study group and 32.9% in the control group. The differences between the two groups in the prevalence of the midline deviation were statistically significant both in the upper and the lower dental arches. No association was found between site, side, or severity of scoliosis and the appearance or site of the malocclusion features examined.
Later, the severity of scoliosis was related to the occlusal relationship again, but no significant relationship was observed between the severity of scoliosis and the occlusal characteristics.
In 2008, in facts, the scoliosis was related again to the Angle class malocclusion,  with the analysis of 28 children with scoliosis at various degree of severity (mean age: 14.7 y; SD: 2.3 y) matched with a control group of 68 orthopedically healthy children (mean age: 14.8 y; SD: 0.11 y). In the group of scoliotic subjects, the indication of the corset was represented by the values of Cobb angle > 20° measured at the level of main curvature, so these children belonged to the severe group. In the analyzed sample, nine children were wearing corset because of the severity of their orthopedic malformation. The moderate subgroup consisted of children with malformations requiring no constant posture correction, namely wearing corset. Besides the clarified different orthopedic situation, the selection criteria of the two groups were: similar age, no previous orthodontic treatment, as well as no missing teeth, carious lesions, or pathologic periodontal status. In this sample, when analyzing the sagittal deviations in the molar region, the incidence rate of the bilateral deviation, being present as a sign of symmetry, as well as of the unilateral occlusal deviation, related to the asymmetry, revealed a significant importance. In the group of adolescents with scoliosis, in fact, the unilateral Angle class II relationship showed a significant higher prevalence respect to the control group (Figure 2). Specifically, in the group of subjects with scoliosis, the 57.12% showed a normal bilateral occlusion, but the 28.56% showed a unilateral Angle class II malocclusion, with a significant higher frequency respect to the health group. This unilateral deviation (unilateral Angle class II malocclusion) was characteristic for almost one-third of scoliotic subjects, while in the control health group its incidence rate was hardly 8.82%. In the group of scoliotic subjects, the unilateral class II relationship was significantly higher frequent then the bilateral class II relationship, pointing on the importance of the asymmetry of malocclusion, in relation to the scoliosis.
These studies are in accordance with what affirmed by Lippold et al. (2003),  that the scoliotic curves occur in the frontal plane and - through the head posture that is tilted sideways -play an important role in the development of the different dentofacial asymmetries. Results of several studies, as seen, confirm a potential correlation between scoliosis and unilateral Class II malocclusion.
Unilateral Class II malocclusion is not the only type of malocclusion significantly associated to the scoliosis.
Segatto et al. (2008)  analyzed also other occlusal characteristics of the frontal region of dental arch and found some other significant differences between the scoliotic and the health groups.
Frequency of the sagittal occlusal anomalies on the molar region, according to the study by Segatto et al. (2008).
Normal molar occlusion (Angle Cl.I) frequency (%)
Distal molar occlusion (Angle Cl.II) frequency(%)
Comparison of the occlusal characteristics of the frontal region, according to the study by Segatto et al. (2008).
mean ± SD (mm)
2.74 ± 1.851
2.55 ± 1.509
2.21 ± 1.201
mean ± SD (mm)
2.58 ± 2.168
2.78 ± 1.715
3.10 ± 1.585
mean ± SD (mm)
2.08 ± 1.121
1.76 ± 0.972
1.47 ± 0.898
Finally, on the basis of the evaluation of cephalograms in the same sample, a slightly protrusive maxilla and a slightly retrusive mandibula (Figure 5), characteristic of a class II skeletal discrepancy, resulted more pronounced in the scoliotic group than in the control group .
In addition to the studies that compared scoliotic to healthy subjects, other investigations underlined a relation between the occlusion and the vertebral column alignment, also in not scoliotic subjects [20, 21].
These studies thus suggest a multidisciplinary orthodontic and orthopaedic approach to patients who do not show any clinical evidence of scoliosis or malocclusion.
The study was performed on a group of fifty-three adult patients (32 women and 21 men; mean age 24.6 years, SD 9.0 years) with skeletal malformations (Class II and III malocclusion) who came to medical center for a consultation regarding an orthodontic treatment, without anamnestically established motor or neurological findings and/or previous internal or orthopaedic illnesses.
In the sample, some correlations were observed with the facial depth (mesial/distal) and the facial axis (vertical/horizontal).
Patients with a vertical value on the facial axis and a skeletal distal value in the facial depth (long face) had a slight pelvic torsion (Figure 9b) where the DL (left crista iliaca posterior superior) was rotated backward with respect to the DR (right crista iliaca posterior superior), while patients with a horizontal facial axis and mesial relation of facial depth (short face) revealed a slight rotation of the DR rotated backward regarding the contralateral side. Although the investigation was performed on subjects without a diagnosed scoliosis, and on the base of a rasterstereographic surface reconstruction of the back profile of a patient (and not a radiographic evaluation of scoliosis), it suggested an extension of the interdisciplinary concepts within the sense that an orthopedic examination can be considered for patients undergoing an orthodontic-operative therapy.
Scoliosis and crossbite (Figure 10)
This relationship was investigated mostly through case-control studies and clinical case-reports. In general, it was stated that left-right asymmetries are among the most common anomalies in patients with scoliosis .
As seen in literature, these anomalies seem to be also evident in the craniofacial complexes of patients with certain malocclusions, as unilateral crossbites (Figure 10), lower midline deviations, and facial asymmetries. Because some asymmetric malocclusions are difficult to correct fully, it was hypothesized that generalized body asymmetry might underlie these malocclusions in some patients .
In a group of subjects controlled from April 2002 through July 2003,  the posteroanterior cephalometric radiographs and chest X-rays from 85 patients with jaw deformities and a control group of 20 patients with no jaw deformities were controlled. To measure the lateral shift of the mandible, a horizontal baseline (X axis) was drawn on the cephalogram connecting the intersection of the external margins of the orbits and the most lateral points of the greater wings of the sphenoid. A vertical baseline (Y axis) was then marked perpendicular to the × axis, intersecting the ethmoid crista galli. Then, the lateral displacement of the mandibular mentum from the Y axis was measured. Displacement to the right was designated positive; that to the left was designated negative. Cobb's method was used to measure scoliosis curves on chest X-rays; the direction of the curve was designated similarly. Of the 85 patients with jaw deformity,  (27.1%) had a Cobb angle exceeding 10°. None of the control group had scoliosis exceeding 10°. No correlation was found between the direction of mandibular displacement and the direction of scoliosis.
In 2008, in the analysis of 28 children with scoliosis (mean age: 14.7 y; SD: 2.3 y) compared with a control group of 68 orthopedically healthy children (mean age: 14.8 y; SD: 0.11 y), three children in the scoliotic group were registered with a unilateral crossbite (Figure 8) while there was only a bilateral crossbite case. In the control group two bilateral crossbite cases matched the three unilateral crossbite cases .
In the same sample, also the degree of the midline deviation (Figure 4), that is a clinical sign associated with the unilateral crossbite, was recorded. The severe type of scoliotic group was characterized by significantly higher prevalence of midline deviation, compared to the control group . Also, this scoliotic group was found to have higher midline deviation values respect to the control group (Table 2).
In 2006, in a group of 96 orthopedic patients with idiopathic scoliosis 17 (79 females and 17 males: mean age, 13.9 y; SD: 3.5 y; range, 6.2-25.3 y), compared with a control group of 705 children, the prevalence of upper midline deviation was 21% in the group of scoliosis and 9.5% in the control group; while the prevalence of lower midline deviation was 53.7% in the study group and 32.9% in the control group. In the same sample, the prevalence of unilateral posterior crossbite was 28.1% and 18.1% respectively in the study and the control group; the prevalence of anterior crossbite was 16.6% in the study group and 9.3% in the control group.
An increased occurrence of orthopaedic alterations in the frontal plane was also observed in children with a unilateral crossbite in another recent study . More specifically, among the children who revealed an asymmetric upper cervical spine, the unilateral crossbite was not necessarily combined with a pathological orthopaedic variable, but statistically, children with a unilateral crossbite showed more often an oblique shoulder, scoliosis, an oblique pelvis, and a functional leg length difference than children with symmetry. No correlation was found between the laterality of the crossbite side and any orthopaedic asymmetry. The study was conducted comparing fifty-five children aged 3-10 years (22 girls and 33 boys) with a unilateral crossbite and 55 gender- and age-matched children with asymmetric upper cervical spine, but no crossbite, who served as the control group, selected from an orthopaedic cohort of 240 patients. The certain asymmetry of the upper cervical region was confirmed in all the subjects by radiographs and palpation.
Also, in 2008, in the analysis of 28 children with scoliosis (mean age: 14.7 y; SD: 2.3 y) compared with a control group of 68 orthopedically healthy children (mean age: 14.8 y; SD: 0.11 y), 18 the clinical examination of the Temporo-mandibular joint (TMJ) at almost a quarter of the scoliotic group revealed a pathological symptom: the mandibular lateral movements showed a reduced range in only one side. More specifically, only half of the patients in the scoliotic group were able to make the same range of bilateral movements. On the contrary, this rate was 82.32% in the control group.
The results of all these cited studies suggest that dental asymmetries correlate with orthopaedic asymmetries in the frontal plane, when the analysis is conducted in a sample of young boys and girls.
However, it must be noted that also the bilateral crossbite was related to the scoliosis. In 2007, also a correlation between scoliosis and bilateral crossbite was reported: in a study on 428 subjects (211 females and 217 males), aged 9 to 14 years, 25 a 2.8% scoliosis incidence has emerged, and an incidence of scoliotic attitudes of 9.5%, with a statistically significant relationship among that disorders of posture, and the presence of ogival palate with bilateral crossbite.
Among the studies on the association between asymmetric occlusion and trunk asymmetry, a few studies must be cited, that have investigated these co-relationship in health subjects without any pathological orthopaedic condition [25–28]. They reported deviating findings: Lippold et al. (2000)  found a statistically significant correlation between midline deviation and oblique pelvis as well as leg length differences, considered in the limits of physiology. The other two studies [26, 27] showed that moderate trunk asymmetry (not pathological condition) did not affect facial asymmetry or vice versa. With regard to the study design and the investigated patients, the three studies can hardly be compared: one  compared 29 children with a right-sided midline shift with 28 children with a symmetric occlusion; Lippold et al. (2000)  investigated midline discrepancies in 50 patients, aged 4-55 y, who were recruited from physiotherapy appointments, while Zepa et al. (2003)  analyzed frontal cephalograms and compared them with rib hump or lumbar prominence and spinal posture.
In order to investigate the possible effects of orthopaedic asymmetric disorders on dentofacial development and head posture, other clinical studies have been previously conducted on patients with scoliosis, and the results given by this previous literature are very similar to the more recent cited studies.
Prager (1980)  interpreted the crossbite as a transmission of the asymmetry of the body, whereas Hirschfelder and Hirschfelder (1983)  considered, although they had not yet clarified transmission, the crossbite to be a new compensatory curvature of a scoliosis. Independent of the different offered explanations of the high prevalence of crossbite in those patients, an interdisciplinary treatment approach to alleviate facial asymmetry and to stabilize head posture, initiated as early as possible, has been unanimously recommended since '60 decade [28, 33, 34].
But it must be underlined that several studies about the association between unilateral crossbite and scoliosis were also conducted on animals, and the obtained results tended to confirm the observations recorded on humans.
Experimental studies also tried to explain the origin and the mechanism for the occurrence of an asymmetric growth of the head due to a unilateral crossbite:  more specifically, this experimental study in rabbits revealed a high level of asymmetry in craniofacial structures, temporomandibular structures and muscle functions in rabbits after an experimentally induced crossbite . Moreover, in patients with a unilateral malocclusion, asymmetric condylar position with an asymmetric condylar path was observed, [28, 39] and this seems to reduce the mandibular condylar growth,  causing an asymmetric mandibular ramus length, that has been observed shorter in the crossbite side [41, 42]. Based on the findings that asymmetric facial structures can be corrected only after early correction of a unilateral crossbite [28, 41, 43] it was suggested that a persisting asymmetric occlusion results in growth restriction that leads to mandibular and facial asymmetry [40, 44–47] and later also to a vertebral column asymmetry. For this type of correlation, the role of the cervical column, as a link tract between the head and the vertebral column has been underlined.
In this field, it has been demonstrated in health subjects, without evident orthopaedic disorders, that craniofacial growth is strongly associated with cervicovertebral anatomy [29, 48]. It has been shown that the upper cervical region reveals a high potential for adaptation to craniofacial growth . This may possibly be due to its important role: the cervical spine provides the morphological basis for an extensive freedom of head movement; then, it serves as a bridge for numerous blood and lymphatic vessels and nerves, linking head, trunk, and upper limb. The mechanism of transmission of an imbalance from the occlusion to the vertebral column may be related to the consequential tilt of the first cervical vertebra that affects the tilt of the adjacent vertebra, so destabilizing the vertical alignment of the cervical spine, also changing the functionality of each cervical muscle; finally, the asymmetrical distribution of loads could then affect the orientation of the other dorsal and lombar vertebrae, contributing to the functional deformity of the spine, finally the scoliosis .
Also, a close relationship among the masticatory muscles and the cervical muscles supporting the head has been demonstrated in patients requiring stomatognathic treatment . In addition, it has been shown that occlusal interference can cause dysfunction of both the cervical spine and the sacro-iliac joint . Consequently, all these authors recommended that the cervical spine and lumbar and pelvic regions should also be investigated in patients with craniomandibular dysfunction. In this field, the intimate developmental relationship between the atlas and the cranial base was also underlined .
In a study previously cited,  in facts, an oblique shoulder was diagnosed in 30.9% of the total group, and in 70.6% of them a unilateral crossbite was observed, suggesting a link among occlusion, cervical spine adaption and occurrence of scoliosis, although no causal relationship was demonstrated.
All the interdisciplinary studies on scoliotic patients are in accordance with the fact that no lateral correlation exists between the side of crossbite and the side of the curvature of the scoliotic spine [30, 31, 49].
Finally, in the analysis of the orthopedic literature, Floman  indicated a possible connection between thoracic scoliosis and restricted head motion in a report of 6 patients. However, it has not been clarified whether such a restriction in head motion had a secondary influence on occlusion.
Discussion and conclusion
As seen, no randomized clinical trials were recorded. The observations were mostly based on case-control studies and clinical case-reports.
Longitudinal cllinical trials with a control group evidenced the association betweeh the first type of brace and the occurrence of a class II relationship induced by the brace; consequently, the clinical controlled trial suggested the use on orthodontic treatment during the treatment of scoliosis with a brace.
The maiority of other studies were case-control studies that evidenced the presence of unilateral class II, midline deviation, increased overjet and unilateral cross-bite in a higher percentage in subjects with scoliosis respect to health subjects.
As seen in this review, there are only few articles which describe the orthodontic examination as an opportunity for the early detection of scoliosis or which emphasize the necessity of early orthodontic check-ups for children with diagnosed scoliosis, highlighting the application of minimal-invasive methods of screening the affected population . Based on their results, however, a dominancy of the dentofacial asymmetry (mostly unilateral crossbite) in the scoliotic group, can be expected, [48, 55] as well as unilateral Angle class II malocclusion and midline deviation. As seen in this review, the data in literature prove also the existence of other dentofacial anomalies in children with scoliosis (ogival palate, increased overjet, reduced overbite, reduced range in lateral movements in one side), although these studies did not analyzed the orthopaedic sample on the base of the scoliotic angle, or the presence of one or more curves, and on the location of the curvature, which may affect the gravity and the type of scoliosis.
Some hypothesis to explain the correlation between the occlusion and the scoliosis can be made, although without certain conclusions.
The assumption on which the hypothesis on this correlation is based is that there is an anatomical and functional relationship between the stomatognathic apparatus and the spinal column. This relationship was hypothesized by several authors, based upon various observations .
Anatomical details: There is an anatomical relationship between the mandible and the cervical column, since the cranium and the mandible have muscular and ligament attachments to the cervical area. The function of the head, neck, and jaws is closely interrelated, forming a combined functional system [55, 56]. observed a significant correlation between mandibular length and cervical lordosis angle on lateral skull radiographs (in natural head position) in Caucasian adult women with a skeletal class II malocclusion. The longer the mandibular body was, the straighter the cervical column appeared to be . In a group of 50 Caucasian adult women with internal derangement, compared with a control group of 50 Caucasian women without internal derangement, cephalometric tracings on lateral skull radiographs in natural head position showed a significantly lower cervical lordosis angle. Beyond possibly causing TMJ diseases, dental malocclusions could, by the same mechanism, be linked to a functional asymmetry of trunk muscles. We suggest that one pathway is through the atlas. The atlas is linked to occipital condyles and thus affect the rest of the spine alignment, leading to further profound compensatory chenges, that may become pathological.
In conclusion, from a clinical point of view, if the asymmetry underlying idiopathic scoliosis and asymmetric malocclusion originates from the same etiology, it might be difficult to fully correct all features of the malocclusion or maintain the correction. This difficulty was observed, for example, in patients with posterior crossbites in whom relapse of lower midline deviations or tendency toward crossbites was evident also after orthodontic treatment. To clarify this point, the possibility of a connection between the reverse cycle in masticatory movements and asymmetrical posture should be evaluated.
In conclusion, all the observed frequent and severe dentofacial deviations in the scoliotic group draw the attention to the necessity of the early examination of this patient group from an orthodontics and orthopaedic point of view.
However, whether scoliosis affects mandibular dentoalveolar symmetry (whether there is a causal relationship) needs further elucidation.
Acknowledgements and Funding
We acknowledge Editage for revision of english language.
- Trobisch P, Suess O, Schwab F: Idiopathic Scoliosis. Dtsch Arztebl Int. 2010, 107: 875-884.PubMedPubMed CentralGoogle Scholar
- Riseborough EJ, Wynne-Davies R: A genetic survey of idiopathic scoliosis in Boston, Massachusetts. J Bone Joint Surg Am. 1973, 55: 974-982.PubMedGoogle Scholar
- Brown JK, Bell E, Fulford GE: Mechanism of deformity in children with cerebral palsy-with special reference to postural deformity. P/idiot Forthidk Praxis. 1982, 53: 78-94.Google Scholar
- Kouwenhoven JW, Castelein RM: The pathogenesis of adolescent idiopathic scoliosis: review of the literature. Spine. 2008, 33: 2898-2908. 10.1097/BRS.0b013e3181891751.View ArticlePubMedGoogle Scholar
- Visscher CM, Lobbezoo F, de Boer W, van der Zaag J, Naeije M: Prevalence of cervical spinal pain in craniomandibular pain patients. Eur J Oral Science. 2001, 109: 76-80. 10.1034/j.1600-0722.2001.00996.x.View ArticleGoogle Scholar
- Alden KJ, Marosy B, Nzegwu N, Justice CM, Wilson AF, Miller NH: Idiopathic scoliosis: Identification of candidate regions on chromosome 19p13. Spine. 2006, 31: 1815-1819. 10.1097/01.brs.0000227264.23603.dc.View ArticlePubMedGoogle Scholar
- White AA, Panjabi MM: Clinical Biomechanics of the Spine. Lippincott. 1990, ISBN 0-397-50720-8, 2Google Scholar
- Hitchcock HP: Treatment of malocclusion associated with scoliosis. Angle Orthod. 1969, 39: 64-68.PubMedGoogle Scholar
- Rock VP, Baker R: The effect of Milwaukee brace upon dentofacial growth. Angle Orthod. 1972, 42: 96-102.PubMedGoogle Scholar
- Dayan N, Abraham Z, Lieberman M: Cephalometric evaluation of an oral stabilizing appliance with the modified Milwuakee brace. Angle Orthod. 1977, 47: 300-303.PubMedGoogle Scholar
- Janicki JA, Poe-Kochert C, Armstrong DG, Thompson GH: A comparison of the thoracolumbosacral orthoses and providence orthosis in the treatment of adolescent idiopathic scoliosis: results using the new SRS inclusion and assessment criteria for bracing studies. J Pediatr Orthop. 2007, 27: 369-374. 10.1097/01.bpb.0000271331.71857.9a.View ArticlePubMedGoogle Scholar
- Herring JA: Tachdjian's Pediatric Orthopaedics. 2002, Philadelphia PA: W.B. SaundersGoogle Scholar
- Pavsic J: The effect of orthodontic measures on the growth of the mandible in scoliosis patients during treatment with the Milwaukee brace. Stomatol DDR. 1983, 33: 676-82.PubMedGoogle Scholar
- Luedtke GL: Management of the dentition of patients under treatment for scoliosis using the Milwaukee brace. Am J Orthod. 1970, 57: 607-14. 10.1016/0002-9416(70)90188-0.View ArticlePubMedGoogle Scholar
- Pećina M, Lulluć-Dukić O, Pećina-Hrncević A: Hereditary orthodontic anomalies and idiopathic scoliosis. Int Orthop. 1991, 15: 57-59. 10.1007/BF00210536.View ArticlePubMedGoogle Scholar
- Ben-Bassat Y, Yitschaky M, Kaplan L, Brin I: Occlusal patterns in patients with idiopathic scoliosis. Am J Orthod Dentofac Orthop. 2006, 130: 629-633. 10.1016/j.ajodo.2005.01.032.View ArticleGoogle Scholar
- Segatto E, Lippold C, Végh A: Craniofacial features of children with spinal deformities. BMC Musculoskelet Disord. 2008, 22;9: 169-View ArticleGoogle Scholar
- Lippold C, van den Bos L, Hohoff A, Danesh G, Ehmer U: Interdisciplinary study of orthopedic and orthodontic findings in pre-school infants. J Orofac Orthop. 2003, 64: 330-340. 10.1007/s00056-003-0236-4.View ArticlePubMedGoogle Scholar
- Lippold C, Danesh G, Hoppe G, Drerup B, Hackenberg L: Trunk Inclination, Pelvic Tilt and Pelvic Rotation in Relation to the Craniofacial Morphology in Adults. Angle Orthod. 2007, 77: 29-35. 10.2319/121205-434R.1.View ArticlePubMedGoogle Scholar
- Burwell RG: Aetiology of idiopathic scoliosis: current concepts. Pediatr Rehabil. 2004, 6: 137-170.View ArticleGoogle Scholar
- Ikemitsu H, Zeze R, Yuasa K, Izumi K: The relationship between jaw deformity and scoliosis. Oral Radiol. 2006, 22: 14-17. 10.1007/s11282-006-0039-6.View ArticleGoogle Scholar
- Korbmacher H, Koch L, Eggers-Stroeder G, Kahl-Nieke B: Associations between orthopaedic disturbances and unilateral crossbite in children with asymmetry of the upper cervical spine. Eur J Orthod. 2007, 29: 100-104. 10.1093/ejo/cjl066.View ArticlePubMedGoogle Scholar
- Pedrotti L, Mora R, Bertani B, Tuvo G, Crivellari I: Association among postural and skull-cervico-mandibular disorders in childhood and adolescence. Analysis of 428 subjects. Pediatr Med Chir. 2007, 29: 94-98.PubMedGoogle Scholar
- Lippold C, Ehmer U, van den Bos L: Beziehungen zwischen kieferorthopädischen und orthopädischen Befunden. Manuelle Medizin. 2000, 38: 346-350. 10.1007/s003370070007.View ArticleGoogle Scholar
- Dußler E, Raab P, Kunz B, Kirschner S, Witt E: Mandibuläre Mittellinienverschiebungen und Asymmetrien des Halte- und Bewegungsapparates bei Kindern und Jugendlichen. Manuelle Medizin. 2002, 40: 116-119.Google Scholar
- Zepa I, Hurmerinta K, Kovero O, Nissinen M, Könönen M, Huggare J: Trunk asymmetry and facial symmetry in young adults. Acta Odontol Scand. 2003, 61: 149-153. 10.1080/00016350310001695.View ArticlePubMedGoogle Scholar
- Pirttiniemi P, Kantomaa T, Lahtela P: Relationship between craniofacial and condyle path asymmetry in unilateral cross-bite patients. Eur J Orthod. 1990, 12: 408-413.View ArticlePubMedGoogle Scholar
- Huggare J: Postural disorders and dentofacial morphology. Acta Odontol Scand. 1998, 56: 383-386. 10.1080/000163598428374.View ArticlePubMedGoogle Scholar
- Prager A: Vergleichende Untersuchungen über die Häufigkeit von Zahnstellungs- und Kieferanomalien bei Patienten mit Deformitäten der Wirbelsäule. Fortschr Kieferorthop. 1980, 41: 163-168. 10.1007/BF01995079.View ArticleGoogle Scholar
- Hirschfelder U, Hirschfelder H: Auswirkungen der Skoliose auf den Gesichtsschädel. Fortschr Kieferorthop. 1983, 44: 457-467. 10.1007/BF02005965.View ArticlePubMedGoogle Scholar
- Müller-Wachendorff R: Untersuchungen über die Häufigkeit des Auftretens von Gebißanomalien in Verbindung mit Skelettdeformierungen mit besonderer Berücksichtigung der Skoliosen. Fortschr Kieferorthop. 1961, 22: 399-408. 10.1007/BF02198266.View ArticleGoogle Scholar
- Peéina M, Lulié-Dukié O, Peéina-Hrn , INCLUDEPICTURE: Hereditary orthodontic anomalies and idiopathic scoliosis. Int Orthop. 1991, 15: 57-59. 10.1007/BF00210536. [http://ejo.oxfordjournals.org/math/ccaron.gif\*MERGEFORMATINETeviéA]View ArticleGoogle Scholar
- Festa F, D'Attilio M, Vecchiet F: Effects of a horizontal oscillation of the mandible on the spinal column of the rat in vivo using radiographic monitoring. Orthognatodonzia Italiana. 1997, 6: 539-550.Google Scholar
- Azuma Y, Maehara K, Tokunaga T, Hashimoto M, Ieoka K, Sakagami H: Systemic effects of the occlusal destruction in guinea pigs. In Vivo. 1999, 13: 519-524.PubMedGoogle Scholar
- D'Attilio M, Filippi MR, Femminella B, Festa F, Tecco S: The influence of an experimentally-induced malocclusion on vertebral alignment in rats: a controlled pilot study. J Craniomandib Pract. 2005, 23: 119-129.Google Scholar
- Poikela A, Kantomaa T, Pirttiniemi P: Craniofacial growth after a period of unilateral masticatory function in young rabbits. Eur J Oral Sci. 1997, 105: 331-337. 10.1111/j.1600-0722.1997.tb00249.x.View ArticlePubMedGoogle Scholar
- Nerder PH, Bakke M, Solow B: The functional shift of the mandible in unilateral posterior crossbite and the adaptation of the temporomandibular joints: a pilot study. Eur J Oral Sci. 1999, 21: 155-166.Google Scholar
- Tadej G, Engström C, Borrman H, Christiansen EL: Mandibular condyle morphology in relation to malocclusions in children. Angle Orthod. 1989, 59: 187-194.PubMedGoogle Scholar
- Schmid W, Mongini F, Felisio A: A computer-based assessment of structural and displacement asymmetries of the mandible. Am J Orthod Dentofac Orthop. 1991, 100: 19-34. 10.1016/0889-5406(91)70045-X.View ArticleGoogle Scholar
- Santos Pinto A, Buschang PH, Throckmorton GS, Chen P: Morphological and positional asymmetries of young children with functional unilateral posterior crossbite. Am J Orthod Dentofac Orthop. 2001, 120: 13-20.View ArticleGoogle Scholar
- Mimura H, Deguchi T: Relationship between craniofacial and condyle path asymmetry in unilateral crossbite patients. J Craniomandib Pract. 1994, 12: 161-166.Google Scholar
- Pirttiniemi P, Raustia A, Kantomaa T, Pyhtinen J: Relationships of bicondylar position to occlusal asymmetry. Eur J Orthod. 1991, 12: 441-445.View ArticleGoogle Scholar
- O'Bryrn BL, Sadowsky C, Schneider B, BeGole EA: An evaluation of mandibular asymmetry in adults with unilateral posterior crossbite. Am J Orthod Dentofac Orthop. 1995, 107: 394-400. 10.1016/S0889-5406(95)70092-7.View ArticleGoogle Scholar
- Hesse KL, Årtun J, Joondeph DR, Kennedy DB: Changes in the condylar position and occlusion associated with maxillary expansion for correction of functional unilateral posterior crossbite. Am J Orthod Dentofac Orthop. 1997, 111: 410-418. 10.1016/S0889-5406(97)80023-6.View ArticleGoogle Scholar
- Langberg BL, Arai K, Miner RM: Transverse skeletal and dental asymmetry in adults with unilateral posterior crossbite. Am J Orthod Dentofac Orthop. 2005, 127: 6-16. 10.1016/j.ajodo.2003.10.044.View ArticleGoogle Scholar
- Solow B, Siersbæk-Nielsen S: Cervical and craniocervical posture as predictors of craniofacial growth. Am J Orthod Dentofac Orthop. 1992, 101: 449-458. 10.1016/0889-5406(92)70119-U.View ArticleGoogle Scholar
- Wong ML, Sandham A, Ang PK, Wong DC, Tan WC, Huggare J: Craniofacial morphology, head posture, and nasal respiratory resistance in obstructive sleep apnoea: an inter-ethnic comparison. Eur J Orthod. 2005, 27: 91-97. 10.1093/ejo/cjh077.View ArticlePubMedGoogle Scholar
- Huggare JA, Raustia AM: Head posture and cervicovertebral and craniofacial morphology in patients with craniomandibular dysfunction. J Craniomandib Pract. 1992, 10: 173-177.Google Scholar
- Fink M, Stiesch-Scholz M, Tschernitschek H: The functional relationship between the craniomandibular system, cervical spine, and the sacroiliac joint: a preliminary investigation. J Craniomandib Pract. 2003, 1: 202-208.Google Scholar
- Ludvig KS: Die Frühentwicklung des Atlas und der Occipitalwirbel beim Menschen. Acta Anatomica. 1957, 30: 444-461. 10.1159/000141222.View ArticleGoogle Scholar
- Floman Y: Thoracic scoliosis and restricted head motion: a new syndrome? A report of six cases. Eur Spine J. 1998, 7: 155-157. 10.1007/s005860050046.View ArticlePubMedPubMed CentralGoogle Scholar
- Korbmacher H, Eggers-Stroeder G, Koch L, Kahl-Nieke B: Correlations between dentition anomalies and diseases of the of the postural and movement apparatus--a literature review. J Orofac Orthop. 2004, 65: 190-203. 10.1007/s00056-004-0305-3.View ArticlePubMedGoogle Scholar
- Zepa I, Hurmerinta K, Kovero O, Nissinen M, Könönen M, Huggare J: Associations between thoracic kyphosis, head posture, and craniofacial morphology in young adults. Acta Odontol Scand. 2000, 58: 237-242. 10.1080/00016350050217064.View ArticlePubMedGoogle Scholar
- Okeson JP, ed: Orofacial pain. Guidelines for assessment, diagnosis, and management. The American Academy of Orofacial Pain. 1996, Chicago: Quintessence, 197-
- Festa F, Tecco S, Dolci M, Ciuffolo F, Di Meo S, Filippi MR, Ferritto AL, D'Attilio M: Relation between cervical lordosis and facial morphology in Caucasian adult women with a skeletal class II malocclusion: a transversal study. J Craniomandib Pract. 2003, 21: 121-129.Google Scholar
- D'Attilio M, Tecco S, Dolci M, Ciuffolo F, Epifania E, Filippi MR, Festa F: Cervical lordosis angle measured on lateral cephalograms: findings in skeletal class II female subjects with and without TMD. A cross-sectional study. J Craniomandib Pract. 2004, 22: 17-44.Google Scholar
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