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Table 1 Transmission of alleles of MATN1 gene in the 81 families of the study and ETDT results

From: Evidence of a linkage between matrilin-1 gene (MATN1) and idiopathic scoliosis

Allele

T

NT

T.R.

χ2

p

Chi-square statistics

99 bp

2

6

25%

  

χ2 for "allele-wise" ETDT = 6.355804, 2 gl, p = 0.041757

101 bp

28

43

39%

3.169

0.0751

χ2 for "genotype-wise" ETDT = 11.007881, 3 gl, p = 0.011743

103 bp

45

26

63%

5.0585

0.0242

χ2 for goodness-of-fit "allele-wise" model = 4.65207, 1 gl, p = 0.03106

  1. T = number of transmitted alleles; NT = number of non-transmitted alleles; T.R.: transmission rate (%) = T/(T+NT) × 100.
  2. ETDT is calculated as χ2 = (T - NT)2/(T + NT), 1 d.f. for each allele and consequently a logistic regression is performed outputting chi-squared statistics with 2 d.f. for allele-wise analysis and 3 d.f. for genotype-wise analysis.
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Scoliosis and Spinal Disorders

ISSN: 2397-1789

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