Figure 2From: Adolescent idiopathic scoliosis (AIS), environment, exposome and epigenetics: a molecular perspective of postnatal normal spinal growth and the etiopathogenesis of AIS with consideration of a network approach and possible implications for medical therapy Normal embryonic development over time initiated by genetic factors (green) and environmental factors (internal blue, external orange ) leading to the normal phenotype (blue). Small arrows represent epigenetic interactions occurring at call, tissue, structure and organ levels (Modified from Jamniczky et al [140]).Back to article page