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Table 2 Comparisons on the clotting capabilities, haemoglobin change, blood products transfused, and total blood loss in patients with or without using TXA

From: Use of Tranexamic Acid (TXA) on reducing blood loss during scoliosis surgery in Chinese adolescents

Surgical parameters Tranexamic acid P
  TXA (N = 55) Control (N = 35)  
Clotting capability    
 Pre-op PT 11.56 ± 0.87 11.32 ± 1.04 0.24
 Pre-op INR 1.07 ± 0.07 1.05 ± 0.06 0.18
 Pre-op APTT 37.24 ± 3.88 37.92 ± 4.83 0.46
Haemoglobin change    
 Latest postop – preop −2.99 ± 1.58 −3.33 ± 1.56 0.33
Equivalent volume of whole blood/packed red blood cell transfused    
 Intra-operative 472.50 ± 370.48 891.67 ± 358.35 0.04
 Post-operative 150.00 ± 256.04 333.33 ± 516.40 0.45
Volume of cell saver blood transfused back to patient (ml) 575.36 ± 412.25 1684.26 ± 1233.91 <0.01
Volume of platelet transfused (ml) 194.41 ± 125.19 219.28 ± 144.17 0.59
Volume of fresh frozen plasma (FFP) transfused (ml) 798.86 ± 520.00 863.18 ± 458.48 0.67
Latest post-operative hemoglobin level 10.00 ± 1.18 9.66 ± 0.75 0.34
Number of days for hemoglobin level reaching stable level post-operatively 4.39 ± 2.12 4.23 ± 1.69 0.80
Total blood loss by anesthetist estimation (ml) 1826.11 ± 1081.45 3889.60 ± 2440.80 <0.01
Total blood loss per segment (ml/segment) 135.62 ± 78.10 328.44 ± 222.68 <0.01
  1. TXA tranexamic acid used, Control none used, PT prothrombin time, INR international normalised ratio, APTT activated partial thromboplastin time