Fig. 1From: Adolescent idiopathic scoliosis (AIS): a multifactorial cascade concept for pathogenesis and embryonic originCascade Concept for AIS pathogenesis based on the findings of Clark et al. [4] that place adipose tissue and energy control in relation to the predisposition to AIS. It is speculated that leptin is linked to human central nervous system development, asynchronous neuro-osseous growth mechanism, and the dorsal shear mechanism. NCS = neurocentralsynchondrosis, GP = growth plateBack to article page