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Volume 10 Supplement 1

IRSSD 2014 Meeting Abstracts

  • Oral presentation
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Altered anisotropy and diffusivity of medulla oblongata and spinal cord in adolescent idiopathic scoliosis


Abnormal somatosensory evoked potentials (SEP) have been demonstrated above the C5-6 level of the spinal cord. Together with observation of tonsillar ectopia and relatively tethered cord, we hypothesize that there is abnormal changes of the white matter integrity along the brainstem and spinal cord. The objective of this study is to utilize the advanced diffusion tensor imaging (DTI) to examine the potential white matter changes of medulla oblongata and spinal cord.

Materials and methods

Thirteen AIS girls with right thoracic curves and thirteen age-matched healthy girls were recruited. DTI of both the brain and the whole spinal cord were acquired on a 3T MRI scanner. Region of interests were manually defined for medulla oblongata and along each intervertebral segment of the spinal cord. Mean values of fractional anisotropy (FA) and mean diffusivity (MD) were computed at the defined regions. Between-group comparisons were performed using the one way of analysis of variance.


Significant decreased FA values and increased MD values were found at the medulla oblongata, C1-2, C2-3, C3-4 and C4-5 segments of the spinal cord in AIS patients compared to normal subjects. No significant difference was found in other segments. There was significant correlation found between tonsillar level and FA value at C4/5 level in AIS patients only.


The DTI findings support our proposed hypothesis of disturbed white matter integrity within the brainstem and spinal cord, which together with low-lying cerebellar tonsils are associated features of tethered cord in AIS. The changes in FA and MD are in line with abnormal SEP observed clinically.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

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Chu, W.C., Kong, Y., Shi, L. et al. Altered anisotropy and diffusivity of medulla oblongata and spinal cord in adolescent idiopathic scoliosis. Scoliosis 10 (Suppl 1), O45 (2015).

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