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Volume 10 Supplement 1

IRSSD 2014 Meeting Abstracts

Serum 25(OH) vitamin d level is associated with treatment outcome of whole-body vibration (WBV) for osteopenia in girls with adolescent idiopathic scoliosis (AIS)


AIS was associated with low bone mass which, apart from being an important health issue that could persist into adulthood, was also a significant prognostic factor for curve progression in AIS. We have performed a randomized controlled trial on WBV and reported its effect on increasing femoral neck areal bone mineral density (aBMD) mainly at the dominant leg but less obviously at the non-dominant side. The objective of this study was to evaluate the role of Vit-D in affecting the anabolic bone effect of WBV.

Material and methods

This was a study nested within a randomized controlled trial with enrolment of 122 AIS girls (15-25 years old) with BMD Z-scores < -1. They were randomly allocated to the Treatment or Control group. The Treatment group received WBV by standing on a low-magnitude high-frequency WBV platform 20 mins/day, 5 days/week (acceleration 0.3g, frequency 35 Hz). The Control group received observation alone. The study period was one year. aBMD at bilateral femoral necks was measured with Dual-Energy X-ray Absorptiometry at baseline and at 12-month. Serum 25(OH)Vit-D level by liquid chromatography tandem mass spectrometry was measured at 6-month within the treatment period.


The mean age was 17.8(SD=1.5) years old and mean Cobb angle was 29.4(SD=8.8) degrees. Subgroup analysis for those with serum 25(OH)Vit-D>40nmol/L revealed not only the positive effects of WBV were greater at both sides, treatment effects were explicitly also noted at the non-dominant leg. In addition, the positive correlation between serum 25(OH)Vit-D and percentage increase in femoral neck aBMD that was not present in the Control group was explicitly detectable in the Treatment group at the non-dominant leg(p=0.004).


The results strongly suggested the treatment effect of WBV could be enhanced through its synergistic factor interaction with Vit-D. The study carried significant clinical implication in that Vit-D insufficiency could affect negatively the treatment outcome of WBV for low bone mass in girls with AIS.

Funding source

General Research Fund, Research Grants Council of Hong Kong (Project no: 467808 and 468809).

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

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Lam, T.P., Ng, B.K.W., Yu, F.W.P. et al. Serum 25(OH) vitamin d level is associated with treatment outcome of whole-body vibration (WBV) for osteopenia in girls with adolescent idiopathic scoliosis (AIS). Scoliosis 10 (Suppl 1), O56 (2015).

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