Objectives
In estrogen receptor 2 (ESR2) gene the rs1256120 polymorphism was described to be associated with predisposition to and severity of idiopathic scoliosis (IS) in Chinese population. This observation has not been confirmed in Japanese population. The ESR2 AluI and RasI site polymorphisms were described to present association with breast cancer, rheumatoid arthritis and bone mineral density, however the association with IS has not been evaluated. The purpose of the study was to investigate associations of the ESR2 polymorphisms with either predisposition to or progression of IS in Central European population.