Bone metabolism and bone mineral density in adolescent idiopathic scoliosis
https://doi.org/10.1186/1748-7161-10-S1-P7
© Ishida et al; licensee BioMed Central Ltd. 2015
Published: 19 January 2015
Keywords
Objective
To characterize bone metabolism in AIS patients using bone metabolism markers.
Summary of background data
Although osteopenia is often associated with AIS, bone metabolism in this condition has not been assessed.
Methods
Bone mineral density (BMD) of the lumbar spine and bilateral proximal femurs (dual energy x-ray absorptiometry) and bone metabolism markers {bone formation marker: serum bone alkaline phosphatase (BAP); bone resorption marker: serum tartrate-resistant acid phosphatase serum band 5 (TRAP5b)} were measured in 55 consecutive AIS subjects aged 10 to 18 years-old (mean: 15.6+/-1.7). BMD, body mass index (BMI), and age of menarche were compared between subjects with normal and high values of TRAP5b.
Results
Nineteen subjects (34%) had osteopenia and 17 subjects (31%) had osteoporosis. In 51 AIS subjects (93%), values for BAP were within normal range, while 33 subjects (60%) had high values for TRAP5b. Subjects with high values for TRAP5b had BMDs of the lumbar spine significantly lower than BMDs of patients with normal values of TRAP5b.
Conclusions
The primary cause of low BMD in AIS was increased bone resorption.
Authors’ Affiliations
Copyright
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
