- Oral presentation
- Open Access
Truncal asymmetry in school children: the effect of the parental age at birth
© Grivas et al; licensee BioMed Central Ltd. 2013
Published: 3 June 2013
Truncal back shape asymmetry (TBSA), as thoracic and/or lumbar humps, is the main indicator for referral to clinics during school-screening for IS, and also the most important sign for assessing IS. It is reported that maternal, but not paternal, age at birth is a risk factor for progressive IS.
This report assesses the relation of parental age at birth to the development of TBSA in school children, which has not been evaluated yet.
11,832 (5,855 males, 5,977 females) children and adolescents (5-17 years old, mean age: 11.34±2.79) were screened at their school for TBSA and/or scoliosis. The Prujis scoliometer was used to examine the students in standing, and sitting, forward bending positions. If at least one of the child's measured angles was equal to or exceeded 6 or 7 degrees of scoliometer reading, it was labelled as "Asymmetry 6" and "Asymmetry 7" respectively. The age, standing height and body weight of the children and the parental age were also documented. The parental age at birth and children's BMI were subsequently calculated. Asymmetries were tested for correlation with parental age at birth, which was transformed to a categorical variable in 5-year intervals. Pearson's Chi-squared test for univariate and logistic regression for quantitative univariate and multivariate analysis were used. The SPSS and STATA v. 11.0 statistical packages were used.
Maternal age (MA): Asymmetry6 and asymmetry7, only in boys, tended to decrease significantly as mother's age at birth increased. The significant and inverse effect of MA at birth on the appearance of asymmetry remained, only in boys, after adjusting for the child's age and BMI. Similar findings were documented for paternal age.
The findings of this report indicate that parental age may possibly influence the presentation of TBSA in males, and possibly also in females, but, unexpectedly, by younger more than older mothers. The importance of the present findings is based on the premise that the intrauterine environment is crucial for programming the fetus for various health and disease outcomes throughout life. We suggest the mechanism involves an environmental factor, and by implication, epigenetics.
- De George FV, Fisher RL: Idiopathic scoliosis: genetic and environmental aspects. J Med Genet. 1967, 4 (4): 251-257. 10.1136/jmg.4.4.251.PubMed CentralView ArticlePubMedGoogle Scholar
- James J, Wynne-Davies R: Genetic factors in Orthopaedics. Recent Advances in Orthopaedics. Edited by: Apley AG. 1969, London: ; J & A Churchill Ltd, 1-35.Google Scholar
- Ryan MD, Nachemson A: Thoracic adolescent idiopathic scoliosis: perinatal and environmental aspects in a Swedish population and their relationship to curve severity. J Pediatr Orthop. 1987, 7 (1): 72-77. 10.1097/01241398-198701000-00015.View ArticlePubMedGoogle Scholar
- Heijmans BT, Tobi EW, Lumey LH, Slagboom PE: The epigenome: archive of the prenatal environment. Epigenetics. 2009, 4 (8): 526-531. 10.4161/epi.4.8.10265.View ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.