Table 2 The most important single nucleotide variants (SNV) found to be associated with idiopathic scoliosis in GWAS

rs11190870

LBX1 downstream

0.67

0.57

1.2 × 10⁻¹⁹

1.6(1.4–1.7)

Takahashi et al. 2011 [50]

Londono et al. 2014 [51], Gao et al. 2013 [52], Grauers et al. 2015 [53]

rs657507

GPR126 intron

0.32

0.28

1.6 × 10⁻⁴

1.2(1.1–1.4)

Kou et al. 2013 [61]

Xu et al.2015 [62]

Grauers et al. 2015 [53]

rs12946942

Intergenic

0.26

0.21

4.0 × 10⁻⁸

2.0(1.6–2.7)

Miyake et al. 2013 [64]

Grauers et al. 2015 [53]

rs3904778

BNC2

-

-

2.5 × 10⁻¹³

1.2(1.2–1.3)

Ogura et al.2015 [63]

-

rs6137473

PAX1

-

-

2.2 × 10⁻¹⁰

1.3(1.2–1.4)

Sharma et al. 2015 [68]

-