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Adolescent idiopathic scoliosis: natural history and long term treatment effects
Scoliosis volume 1, Article number: 2 (2006)
Adolescent idiopathic scoliosis is a lifetime, probably systemic condition of unknown cause, resulting in a spinal curve or curves of ten degrees or more in about 2.5% of most populations. However, in only about 0.25% does the curve progress to the point that treatment is warranted.
Untreated, adolescent idiopathic scoliosis does not increase mortality rate, even though on rare occasions it can progress to the >100° range and cause premature death. The rate of shortness of breath is not increased, although patients with 50° curves at maturity or 80° curves during adulthood are at increased risk of developing shortness of breath. Compared to non-scoliotic controls, most patients with untreated adolescent idiopathic scoliosis function at or near normal levels. They do have increased pain prevalence and may or may not have increased pain severity. Self-image is often decreased. Mental health is usually not affected. Social function, including marriage and childbearing may be affected, but only at the threshold of relatively larger curves.
Non-operative treatment consists of bracing for curves of 25° to 35° or 40° in patients with one to two years or more of growth remaining. Curve progression of ≥ 6° is 20 to 40% more likely with observation than with bracing. Operative treatment consists of instrumentation and arthrodesis to realign and stabilize the most affected portion of the spine. Lasting curve improvement of approximately 40% is usually achieved.
In the most completely studied series to date, at 20 to 28 years follow-up both braced and operated patients had similar, significant, and clinically meaningful reduced function and increased pain compared to non-scoliotic controls. However, their function and pain scores were much closer to normal than patient groups with other, more serious conditions.
Risks associated with treatment include temporary decrease in self-image in braced patients. Operated patients face the usual risks of major surgery, a 6 to 29% chance of requiring re-operation, and the remote possibility of developing a pain management problem.
Knowledge of adolescent idiopathic scoliosis natural history and long-term treatment effects is and will always remain somewhat incomplete. However, enough is know to provide patients and parents the information needed to make informed decisions about management options.
Scoliosis, simply defined as a lateral curvature of the spine, has been recognized clinically for centuries. The deformity is actually much more complex and to describe more completely and quantify scoliosis deformity, three planar and three dimensional terminology and measurements are required . However, for practical purposes the deformity is most conventionally measured on standing coronal plane radiographs using the Cobb technique .
For a few of the patients an underlying cause can be determined, including congenital changes, secondary changes related to neuropathic or myopathic conditions, or later in life from degenerative spondylosis. However, the cause of most scoliosis is not known and since about 1922 such patients have been diagnosed as having idiopathic scoliosis .
Based on the observation of three distinct peak periods of onset, idiopathic scoliosis has been sub-divided into three groups; infantile, before age 3 years; juvenile, age 5 to eight years; and adolescent, age 10 years until the end of growth . This classification is now widely used [5, 6]. Eighty percent or more of idiopathic scoliosis is of the adolescent variety . As it is often not possible to determine the age of onset, age at presentation/detection is more accurate . Thus, it is likely that there is overlap at the age two/three years infantile/juvenile interface and at the age nine/ten year juvenile/adolescent interface. This is much less likely at the infantile/juvenile interface because most infantile curves present in the first six months of life, the most common curves are left thoracic apex, and males are more frequently affected, whereas the most common juvenile curves are right thoracic apex and females are more frequently affected . This makes juvenile curve similar to adolescent curves. At the juvenile/adolescent interface it is almost certain that many of the younger adolescents had their curve well established during their later juvenile years. As the prognosis with juvenile presentation scoliosis is worse than it is for adolescent presentation scoliosis [5, 6], inclusion of juvenile cases in adolescent series will tend to adversely affect the natural history of adolescent scoliosis.
The remainder of this presentation is devoted to adolescent idiopathic scoliosis, it being recognized that a few juvenile idiopathic scoliosis cases are undoubtedly included in the series cited.
Adolescent idiopathic scoliosis can probably best be considered as a complex genetic trait disorder. There is often a positive family history but the pattern of inherited susceptibility is not clear. Current information suggests that there is genetic heterogeneity . This indicates that multiple potential factors are acting either dependently or independently in its pathogenesis .
The prevalence rate of adolescent idiopathic scoliosis, using a cut-off point of 10° Cobb or more, is approximately 2 % to 2.5% [11, 12]. Prevalence as high as 9.2% has been reported: although only 0.23% required treatment . The differences that have been found between specific populations are thought to be due to genetic factors . However, it is possible that environmental factors may also be involved .
The prevalence is very dependent on curve size cut-off point, decreasing from 4.5% for curves of 6 degrees or more to only 0.29% for curves of 21° or more. It is also very dependent on sex, being equal for curves of 6–10° but 5.4 girls to 1 boy for curves of 21° or more .
The incidence, by year of birth, of treatment (brace or surgery) is remarkably stable averaging 0.26% (range, 0.14–0.43%) over a 23 year period from 1955 through 1977 . The female to male ratio in this treated (brace or surgery) series was 7 to 1. Although the ratio of braced to operated patients wasn't provided, it is generally thought that approximately 0.1% will warrant surgery .
The purpose of this review is to summarize what is known about the natural history of adolescent idiopathic scoliosis after the growth years, as well as the long term effects of treatment. It is based on two untreated series from Sweden [5, 18, 19] and the mostly untreated series from Iowa [20–24]. Treated series cited had at least one and usually two or more of the following features: 10+ years follow up, 80+% follow up, controls, or health related quality of life questionnaire data. The end points considered are death, health impairment, deformity, and quality of life.
In the Stockholm series ninety percent of 113 patients first seen from 1913 to 1918 were followed a minimum of 45 years, or until their death. Mortality was 2.2 times that of the normal population, and may have been higher if the eleven patients lost to follow-up could have been traced. The report had two weaknesses. First, the diagnosis was based on clinical notes which were usually supplemented by full length photographs; radiographs were available for only a few. Although paralytic patients were excluded, the series may have included a few patients with congenital scoliosis. Second, 9% of the series were age 7 to 9 at admission. The Gothenburg series included 130 patients with scoliosis of any cause enrolled from 1927 to 1936 at age 0 to 30 years. In their initial report results were largely given for the group as a whole . The series was updated in 1989 when the minimum follow-up for living patients was 56 years . One hundred fifteen (88%) of the patients were followed, 55 of whom had died. The effects of age of onset, defined as age of disease for polio patients, or first presentation for other patients; diagnosis (polio, rickets or unknown); and curve severity (<70° or >70°) on mortality were studied. There were no deaths in patients with adolescent (age 10–16 years) scoliosis of unknown etiology.
These findings are generally supported by those from the mostly untreated series of patients in Iowa, USA [20–24]. Of 444 idiopathic patients originally studied, 50 (11%) had been operated . Of 358 patients whose deformity began after 8 years of age, 245 were located. Six were not eligible and 24 refused to participate, leaving 215 (60%) available for study. Their age averaged forty-two years (range, 32 – 64) and their follow-up 24 years (range, 20–36). At that point mortality was not significantly greater then expected, 7% versus 5.4% expected . This cohort was next followed at an average of 39.3 years (range, 3151). Of 332 eligible patients, 219 (66%) could be traced and 33 had died for a mortality rate of 15%, not different than the 17% expected in a matched population . Only one of the deaths, a 54 year-old with a 142° thoracic scoliosis, could probably be attributed to cor pulmonale secondary to scoliosis. This cohort was last studied at a mean age of 66 years and mean follow-up of 51 years. An additional 36 patients had died. The mortality rate could be determined for 203 (65%) of the 314 patients eligible for study. Assuming that half of the 127 patients not located were deceased, the probability of surviving to age 65 years for the study group was 0.55 and for a matched population 0.57. Scoliosis potentially contributed to death in 3 of the 36 deceased patients . Their age, curve pattern, and curve size at death were 63 years, thoracic, 140°; 69 years, thoracic, 148°; and 53 years, double, 102°/70° and breast cancer.
Thus, it is safe to say that adolescent idiopathic scoliosis does not result in an increased mortality rate. However, it is also clear that it cannot be said that adolescent idiopathic scoliosis never causes death from cardiopulmonary failure. In a study of 800 patients with idiopathic scoliosis attending a chest clinic over 25 years eleven had died of cardiorespiratory failure due to scoliosis. In ten the curve had first been noticed before age 5 years, but in one it was first noted at 11 years of age . The senior author (MA) has first hand experience with a patient diagnosed with idiopathic scoliosis at age 11 years, 5 months when her right thoracic curve was 40°. At age 12 years 1 month her curve had progressed to 50° and the recommended surgery refused. At age 44 years she died of cardiorespiratory failure and her curve at that time was 150° .
In a group of 45 patients with idiopathic scoliosis aged 16 to 67 years at enrollment the risk of developing respiratory failure and death was assessed over a 20 year period. Respiratory failure occurred only in patients with a predicted vital capacity of less that 45% and curve greater than 110° when enrolled into the study .
Such information is reassuring for the adult patient who has adolescent onset idiopathic scoliosis in approximately the 50–70° range who is not concerned about their appearance and who is not bothered by pain. (Figure 1 and Figure 2)
Natural history/health impairment
Pulmonary symptoms such as shortness of breath, not leading to premature death, may be associated with idiopathic scoliosis. These curves are usually larger, greater than 80° Cobb or with increased rotation, and usually single thoracic curves. Large double curves may also be associated with shortness of breath .
For patients with smaller curves there does not appear to be an increase in dyspnea. Evaluation at a minimum 20 years after completion of treatment showed no difference in dyspnea score for brace treated patients' with average Cobb angle of 40° when compared to age and sex matched controls . Nevertheless pulmonary function does appear to be affected even in patients with relatively small curves . To uncover this effect apparently requires stress testing [30, 31]. It is very likely related to decreased chest wall motion .
Hypertension has been reported in one untreated scoliosis series to be higher than expected . However, the series was not stratified by causation or age of onset for this analysis.
Neurological impairment associated with untreated idiopathic scoliosis would appear to be rare. Lumbar radiculopathy can occur and appears to be confined to the concave side of the curves, particularly the compensatory lumbosacral curve .
At an average of 40.5 years after skeletal maturity 68% of the 133 curves in 102 patients in the Iowa series progressed . Curves initially 30°or less tended not to progress whereas curves more than 30° usually progressed. Single thoracic curves between 50° and 75° were the most likely to progress, an average of 29.4° or about 0.73°/year (29.4°/40.5 years). Others have noted that thoracic curves were the most likely to progress . Additional risk factors for progression of single thoracic curves were those with apical vertebral rotation of more than 30 per-cent and Mehta-angle, a measure developed to differentiate resolving and progressing infantile idiopathic scoliosis , of more than 20° . The lumbar components of double major curves were more likely to progress than the thoracic component. Right lumbar apex curves were twice as likely to progress as left apex lumbar curves. Lack of L5 deep seating and greater than 33% apex rotation were risk factors for progression .
Natural history/quality of life
There are no series of completely untreated adolescent idiopathic scoliosis patients from which to learn the effect of the condition on the patient's quality of life.
The Iowa series, now with an average follow-up of 51 years, is the one with the longest follow-up [20–24]. However, it suffers from selection biases. Eleven per-cent (50/444) of the original cohort were excluded due to surgery and patients first presenting at age 8 and 9 years are included. In addition, the follow-up rate is low, with only 43% (117/271) of living, un-operated eligible patients providing health related quality of life information at latest follow-up . However, it has been suggested that untreated patients who have either been lost to follow-up or who refuse to participate in natural history follow-up studies are those likely to have fewer symptoms .
The Ste-Justine series, with 1,476 (71%) of 2,092 patients followed at least 10 years after referral, is the largest [37–40]. However, the series also has several selection biases. Patients presenting at age 9 years were included. Thirty-eight per-cent [556/1467 (9 missing data points)] of the patients were operated, and "untreated" patients included those for whom bracing was recommended, whether or not it was performed. In addition, response rates were less than 70% for patients with curves less than 20° and for patients who had been under observation for two years or less .
Based on these series and many other individual attempts to gain insight in the natural history of adolescent idiopathic scoliosis, it is possible to gain a good idea, albeit incomplete, of the effect of adolescent idiopathic scoliosis on health related quality of life.
Function, based on outcome measures of work and level of disability, of patients with untreated adolescent idiopathic scoliosis do not appear different than controls . However, this study was conducted over a period of time, and possibly in a population, when disability was less of an option. Based on responses to questionnaires scoliosis of even small size may be associated with difficulty in carrying out physical activities, particularly in females with curves greater than 40° .
Pain severity does not correlate with curve size [21, 39]. Curve pattern may be associated with increased pain . When related, thoracolumbar curves seem the most [24, 34] and double curves the least  likely to be associated with increased pain. Arthritic changes are not associated with increased pain  whereas translatory shift in the thoracolumbar spine may be. .
Self-image, as measured by patient responses on a validated questionnaire scored from 1 (best) to 6 was significantly worse for scoliosis patients than controls, the comparison being 3.6 to 4.2, P = 0.001 . For younger female patients with smaller curves self image was in some instance significantly higher than controls .
Mental health studies have yielded conflicting results. Based on a survey of the Iowa series, it was concluded that there were no mental health problems severe enough to require psychiatric treatment and that the deformities were better tolerated by middle age patients than teenagers . At the most recent follow-up a validated depression questionnaire was used and there were no differences from a control population . However, in an uncontrolled study, it was found that females with thoracic curves greater than 40° were particularly prone to psychological disturbance, it being present in 39% .
In the largely untreated Iowa series the untreated scoliosis did not appear to be detrimental to becoming married or childbearing . Curve progression in untreated scoliosis patients does not appear to be influenced by pregnancy . Older studies indicating that pregnancy and childbearing was affected detrimentally were the completely untreated series that included patients with mixed pathology and larger curves [19, 42].
Such knowledge of AIS natural history as is available, although admittedly incomplete, is detailed enough to provide reassurance about the long term effect of untreated adolescent idiopathic scoliosis for most patients (Figure 3 and Figure 4).
The currently accepted methods of treatment are bracing and surgery.
Bracing has been done for centuries. However, there does not appear to have been any documentation of beneficial effect until after the introduction of the Milwaukee brace  and later with the advent of thermoplastics and the thoraco-lumbo-sacral orthosis .
Although still somewhat controversial the best study to date indicates a small but significant beneficial effect of bracing . In this prospective, multi-center, multi-national, center specific study 247 (86%) of 286 enrolled girls of skeletal age 10 – 16 years and single thoracic curves of 25° to 35° were followed until maturity or dropping from the study because of progression of at least 6° on two separate occasions. At 4 years follow-up the success rate was similar for observation and surface electrical stimulation at 36% and 33% respectively; whereas it was significantly better for bracing 74%, P <0.0001.
This finding was supported by a meta-analysis of 20 studies showing that the weighted mean proportion of success was 0.39 for lateral electrical surface stimulation, 0.49 for observation, and 0.60, 0.62, and 0.93 for bracing 8, 16, or 23 hours per day, respectively. The last was significantly more successful than any other treatment, P < 0.0001 .
What is still more controversial is whether or not a bracing program can decrease the frequency of surgery. However, promising results have recently been reported from two different centers using similar programs combining custom bracing and intensive inpatient rehabilitation. Compared to published series, the frequency of surgery was significantly reduced, by 50% or more [47, 48].
Surgical treatment was initiated in 1914 . When the results were evaluated in 1941 they were found to be poor . As a result of the untiring work of John Moe, Paul Harrington, and many others these results had considerably improved by 1962 [51, 52]. Due to advances in surgery the number of scoliosis curves greater than 100° had dropped considerably by 1973 .
The principle indication for surgery during adolescence is a thoracic curve that will reach 50° or more by skeletal maturity. The other curve patterns are more problematic because of the risk of low back pathology and pain after fusion into the low lumbar spine. However, thoracolumbar curves that will reach 50° to 60° at maturity may also be considered for surgery because of their association with a marked degree of deformity and vertebral translatory shift . The indication for surgery, based on curve size, for double and lumbar curves cannot currently be stated with precision, but conservatism seems appropriate.
The indications for surgery as an adult are pain, appearance, and pulmonary problems, i.e. shortness of breath. However, it is unusual for these symptoms to be severe enough to warrant surgery. In the Iowa series eight patients had later surgery, and while if is difficult to exactly determine the size of the study population they came from, it would appear to be about 221, or 4% requiring surgery during adulthood .
The possibility of increased risk of cancer as a result of the radiation from scoliosis x-rays has been raised. However, the x-ray technology used was much older and there were confounding disease variables .
Although there are some risks associated with surgery they have decreased substantially. Death is very unlikely but can occur, especially in patients operated as adults.  Neurological complications, for all cases of spine deformity reported by fellows of the Scoliosis Research Society, was 0.94% from 1965–71 . By 2001–03 this had decreased to 0.49% for adolescent idiopathic scoliosis patients age 10–17 years . Other complications include acute and delayed deep infection, pseudarthrosis, and implant prominence.
Long term treatment effect
We are aware of only one long term series, with minimum 20 year follow-up, studying the effect of bracing. It is accompanied by a companion surgical outcome study [28, 57–59]. There are at least three additional surgical series with a minimum 19 year follow-up [60–62]. And, there are five more series with a minimum follow-up of 10 years. [63–67] In contrast, there appears to be only two series of adolescent idiopathic scoliosis patients first treated surgically as adults [54, 68]. Thus, the long term treatment effects are largely those of surgery, especially ones performed during adolescence. Some other focused studies help provide a picture of the long term effects of treatment, at least to about 20 years post treatment.
With Harrington Instrumentation and arthrodesis curve correction is about 50% initially, with a wide range from 28 to 63% [57, 60, 61]. However, this decreases to about 40% at follow-up, although in one series it was only 15% . Curve correction initially is similar for Cotrel-Dubousset instrumentation, but at follow-up is significantly better in the one series comparing the two, 42% compared to 15% .
Degenerative changes on lumbar spine radiographs have been noted with equal frequency in braced and Harrington instrumentation operated patients, 16% and 24%, both significantly greater than the control frequency of 0. Degenerative changes were not affected by the lower level of instrumentation . However, when studied with flexion and extension dynamic radiographs, patients instrumented with Harrington instrumentation to L3 or L4 had significantly more translational motion than a comparison, asymptomatic group. Furthermore, increased translational motion correlated with increased back pain . Utilizing both lateral flexion-extension dynamic radiographs and MRI, 60% of patients instrumented with Cotrel-Dubousset instrumentation had at least one degenerative abnormality at a minimum of 10 years post operatively. However, this is similar to those reported for asymptomatic populations of similar age .
The advisability of ending instrumentation above lumbar 4, or even 3, is still debated, with published studies apparently fairly evenly divided on the issue. However, if viewed from the vantage point of salvage surgery, 61% of 41 idiopathic scoliosis patients previously operated and requiring instrumentation and arthrodesis to the pelvis had lumbar 4 as their lower instrumented vertebra. Their primary surgery had been done an average of 19 (range, 2 – 45) years earlier . It has been suggested that 10 years is not long enough to know the long term effects on the unfused lumbar spine . Based on this current review, it may be that a minimum 20 years isn't long enough either.
The un-instrumented spine above the instrumentation is not mentioned in any of the long-term follow-up studies. Recently proximal junctional kyphosis has become a topic of increasing interest leading to the concern that it may be an effect of the newer, stiffer instrumentation constructs.
At 12 to 21+ years follow up the re-operation rate for patients operated as adolescents ranges from 5.7% for curve related procedures only  to 22%  and 29%  for all indications. For patients operated as adults and followed relatively shorter periods, i.e. 2–17 years, re-operation rates appear to be 14–15% [54, 68].
Pulmonary function is significantly improved at a minimum of 20 years follow-up in both braced and operated patients .
Pregnancy, childbearing and delivery experience of braced and operated patients are similar to controls, including the rate of low back pain, with only a few exceptions. Braced patients were older at first pregnancy and vacuum extractions were higher in the surgically treated group. Sexual function, largely due to appearance self-consciousness rather than pain, was significantly limited for both surgical and braced patients, more so for the surgical patients, compared to controls .
Spinal mobility is decreased, more so with Harrington than Cotrel-Dubousset instrumentation [61, 65]. Trunk strength for both Harrington and Cotrel-Dubousset instrumented patients was similar to age and sex-adjusted reference values, although patients with Cotrel-Dubousset instrumentation performed significantly better in squatting . These differences may be explained by the one vertebra longer instrumentation, lower end instrumented vertebral level, older age, and longer follow-up of the Harrington series. There were significantly more complications in the Cotrel-Dubousset series .
Health related quality of life
Physical function is lower for braced and operated patients than controls but better when compared to other patient groups with more severe diseases processes . The lower extent of the caudal fusion is associated with more lifting, running, standing and carrying problems .
Pain reported by operated scoliotic patients is more than non scoliotic controls [40, 59, 60, 63]. In addition only those with surgery had pain management problems . Pain level in post surgical patients has been associated with increased kyphosis and increased compensatory thoracolumbar/lumbar curves . In patients operated in adulthood the pain appears to be less than in comparable, unoperated patients but is still greater than controls . Patients with thoracic and double curves improved whereas thoracolumbar curves were not improved. Peak pain levels were similar to a non scoliotic control population but average pain intensity remained higher .
Self image is decreased during the treatment period for both braced and operated patients. Following completion of treatment brace patients return to normal. At an average of 7 years post-operative small differences persisted for the operated patients, the differences characterized as probably "more statistical than practical" . However, in a series followed a minimum of 20 years, surgically treated patients significantly limited social activities due to their back .
Mental health, as determined by the mental health domain as well as the mental component summary of the SF-36 did not show any difference among surgical, brace and control groups at a minimum of 20 years post-surgery in one study .However, in another study of patients also operated with Harrington instrumentation the mental component summary score was significantly lower than age matched population norms, but the actual differences were small, 48.89 compared to 51.44 respectively, and likely not clinically meaningful .
Knowledge of the natural history of adolescent idiopathic scoliosis has expanded greatly in the last two decades. It has become clear that only about one in ten curves progresses to the point that treatment with bracing is warranted, and only one in 25, or 0.1%, to the point that surgery is warranted.
Compared to controls untreated adolescent idiopathic scoliosis does not result in an increased mortality rate. However, it may on rare occasion progress to the point of causing death by cor pulmonale. The rate of dyspnea is slightly increased and is associated with thoracic curves of greater than 80°. Most patients with untreated adolescent idiopathic scoliosis function at or near normal levels, even though pain is more prevalent. Self image is often slightly diminished. Mental health is usually normal.
Bracing appears to prevent about 20% to 40% of appropriately braced curves from progressing 6° or more.
Surgery, consisting of instrumentation and arthrodesis has virtually eliminated large thoracic curves. Although most patients are satisfied with their results, follow-up at 20+ years shows significant, clinically relevant decrease in function and increase in pain compared to controls. Re-operation is required in 6 to 29%. And, a very few have pain management problems.
Even though the natural history and long term treatment effects on adolescent idiopathic scoliosis have become a lot clearer, there are still many unknowns. Non-operative treatment effectiveness is limited and needs to be improved. Selection of adolescent patients for surgery is usually straightforward for major thoracic curves, but is much more problematic for double, lumbar and even thoracolumbar curves. This is because of the low level of instrumentation and arthrodesis required, and the resulting stress concentration on the remaining mobile lumbar motion segments. While ten to twenty-five years is a long term follow-up after treatment, the patients are still relatively young, 30 to 40 years of age. Longer periods of follow-up are needed as they become increasing difficult to accomplish.
Stokes IAF: Three dimensional terminology of spinal deformity: A report presented to the Scoliosis research Society by the Scoliosis Research Society Working Group on 3-D Terminology of Spinal Deformities. Spine. 1994, 19: 236-248.
Cobb JR: Outline for the study of scoliosis. AAOS, Instructional Course Lectures. Edited by: Edwards JW. 1948, Ann Arbor:The American Academy of Orthopaedic Surgeons, 5: 261-75.
Kleinberg S: The operative treatment of scoliosis. Arch Surg. 1922, 5: 631-645.
James JIP: Idiopathic scoliosis: The prognosis, diagnosis, and operative indications related to curve patterns and the age of onset. J Bone Joint Surg Br. 1954, 36: 36-49.
Pehrsson K, Larsson S, Oden A, Nachemson A: Long-term follow-up of patients with untreated scoliosis: A study of mortality, causes of death, and symptoms. Spine. 1992, 17: 1091-1096.
Robinson CM, McMaster MJ: Juvenile idiopathic scoliosis: Curve patterns and prognosis in one hundred and nine patients. J Bone Joint Surg Am. 1996, 78A: 1140-1148.
Riseborough EJ, Wynne-Davies R: A genetic survey of idiopathic scoliosis in Boston, Massachusetts. J Bone Joint Surg Am. 1973, 55: 974-982.
Sevastik JA, Stokes IAF: Idiopathic scoliosis: Terminology. Spine: State of the Art Reviews. 2000, 14: 299-303.
McMaster M: Infantile idiopathic scoliosis: Can it be prevented?. J Bone Joint Surg Br. 1983, 65: 612-617.
Miller NH: The role of genetic factors in the etiology of idiopathic scoliosis. Spine: State of the Art Reviews . 2000, 14: 313-317.
Kane WJ: Scoliosis Prevalence: A call for a statement of terms. Clin Orthop. 1977, 126: 43-46.
Robin GC: The Etiology of Idiopathic Scoliosis. 1990, Boca Raton, FL: CRC Press, 43-60.
Nissinen M, Heliövaara M, Ylikoski M, Poussa M: Trunk asymmetry and screening for scoliosis: A longitudinal cohort study of pubertal schoolchildren. Acta Paediatr. 1993, 82: 77-82.
Grivas TB, Mouzakis V, Vasiliadis E, Mihas K, Polyzois VD: Why the prevalence of AIS is different in various countries? Relation to geographic latitude and the possible role of the age at menarche. Proceedings of IMAST: 7–9 July 2005; Banff. Edited by: Lawrence G. 2005, Lenke: Scoliosis Research Society, paper 48
Rogala EJ, Drummond DS, Gurr J: Scoliosis: Incidence and natural history. J Bone Joint Surg Am. 1978, 60: 173-176.
Montgomery F, Willner S: The natural history of idiopathic scoliosis: Incidence of treatment in 15 cohorts of children born between 1963 and 197. Spine. 1997, 22: 772-774. 10.1097/00007632-199704010-00012.
Taylor TKF, Cumming RG, Jones FL, McCann RG, Plunkett-Cole M: The epidemiology and demography of adolescent idiopathic scoliosis. Spine: State of the Art Reviews. 2000, 14: 305-311.
Nachemson A: A long term follow-up study of non-treated scoliosis. Acta Orthop Scandinav. 2000, 39: 466-476.
Nilsonne U, Lundgren K-D: Long-term prognosis in idiopathic scoliosis. Acta Orthop Scandinav. 1968, 39: 456-465.
Collis DK, Ponseti IV: Long-term follow up of patients with idiopathic scoliosis not treated surgically. J Bone and Joint Surg Am. 1969, 51: 425-445.
Ponseti IV, Freidman B: Prognosis in Idiopathic scoliosis. J Bone Joint Surg Am. 1950, 32: 381-395.
Weinstein SL, Dolan LA, Spratt KF, Peterson KK, Spoonamore MJ, Ponseti IV: Health and function of patients with untreated idiopathic scoliosis: A 50 year natural history study. JAMA. 2003, 289: 559-567. 10.1001/jama.289.5.559.
Weinstein SL, Ponseti IV: Curve progression in idiopathic scoliosis. J Bone Joint Surg Am. 1983, 65: 447-455.
Weinstein SL, Zavala DC, Ponseti IV: Idiopathic scoliosis. Long term follow up and prognosis in untreated patients. J Bone Joint Surg Am. 1981, 63: 702-712.
Branthwaite MA: Cardiorespiratory consequences of unfused idiopathic scoliosis. Br J Dis Chest. 1986, 80: 360-69. 10.1016/0007-0971(86)90089-6.
Landry C, Labelle H, Danserau , Liberge J, Asher M, De Guise J: Charactéristiques morphométriques d'un rachis scoliotique. Ann Chir. 1998, 52: 784-790.
Pehrsson K, Bake B, Larsson S, Nachemson A: Lung function in adult idiopathic scoliosis: A 20 year follow up. Thorax. 1998, 46: 476-478.
Pehrsson K, Danielsson A, Nachemson A: Pulmonary function in patients with adolescent idiopathic scoliosis: A 25 year follow-up after surgery or start of brace treatment. Thorax. 2001, 56: 388-393. 10.1136/thorax.56.5.388.
Mankin H, Graham J, Schauk J: Cardiopulmonary function in mild and moderate scoliosis. J Bone and Joint Surg. 1964, 46A: 53-62.
Chong K, Letts R, Cumming G: Influence of spinal curvature on exercise capacity. J Ped Orthop. 1981, 1: 251-254.
Barrios C, Pérez-Encinas C, Maruenda JI, Laguía M: Significant ventilatory functional restriction in adolescents with mild or moderate scoliosis during maximal exercise tolerance test. Spine. 2005, 30: 1610-1615. 10.1097/01.brs.0000169447.55556.01.
Kotani T, Minami S, Takahashi K, Isobe K, Nakata Y, Takaso M, Inoue M, Maruta T, Akazawa T, Ueda T, Moriya H: An analysis of chest wall and diaphragm motions in patients with idiopathic scoliosis using dynamic breathing MRI. Spine. 2004, 29: 298-302. 10.1097/01.BRS.0000106490.82936.89.
Jackson RP, Simmons EH, Stripinis D: Incidence and severity of back pain in adult idiopathic scoliosis. Spine. 1983, 8: 749-756.
Ascani E, Bartolozzi P, Logroscino A, Marchetti PG, Ponte A, Savini R, Travaglini F, Binazzi R, Silvestre MDI: Natural history of untreated idiopathic scoliosis after skeletal maturity. Spine. 1986, 11: 784-789.
Mehta MH: The rib vertebral angle in the early diagnosis between resolving and progressive infantile scoliosis. J Bone Joint Surg. 1972, 54-B: 230-243.
Motulsky AG: Biased ascertainment and the natural history of diseases. New England J Med. 1978, 298: 1196-1197.
Goldberg MS, Mayo NE, Poitras B, Scott S, Hanley J: The Ste-Justine adolescent idiopathic scoliosis cohort study: Part I: Description of the study. Spine. 1994, 19: 1551-1561.
Goldberg MS, Mayo NE, Poitras B, Scott S, Hanley J: The Ste-Justine adolescent idiopathic scoliosis cohort study: Part II: Perception of health, self and body image, and participation in physical activities. Spine. 1994, 19: 1562-1572.
Mayo NE, Goldberg MS, Poitras B, Scott S, Hanley J: The Ste-Justine idiopathic scoliosis cohort study. Part III: Back pain. Spine. 1994, 19: 1573-1581.
Poitras B, Mayo NE, Goldberg MS, Scott S, Hanley J: The Ste-Justine adolescent idiopathic scoliosis cohort study. Part IV: Surgical correction and back pain. Spine. 1994, 9: 1582-1588.
Betz RR, Bunnell WP, Lamrecht-Mulier E: Scoliosis and pregnancy. J Bone Joint Surg Am. 1987, 69: 90-96.
Kolind-Sørensen V: A follow-up study of patients with idiopathic scoliosis [abstract]. Acta Orthop Scand. 1973, 44: 98-
Blount W, Schmidt AC, Keever D, Leonard ET: The Milwaukee brace in the operative treatment of scoliosis. J Bone Joint Surg Am. 1958, 40: 526-529.
Watts HG, Hall JE, Stanish W: The Boston brace system for the treatment of low thoracic and lumbar scoliosis by the use of girdle without superstructure. Clin Orthop. 1977, 126: 87-92.
Nachemson AL, Peterson L-E: Members of the Brace Study Group of the Scoliosis Research Society: Effectiveness of treatment with a brace in girls who have adolescent idiopathic scoliosis: A prospective, controlled study based on data from the brace study of the Scoliosis Research Society. J Bone Joint Surg Am. 1995, 77: 815-822.
Rowe DE, Bernstein SM, Riddick MF, Adler F, Emans JB, Gardner-Bonneau E: A meta-analysis of the efficacy of non-operative treatment for idiopathic scoliosis. J Bone Joint Surg Am. 1997, 79: 664-674.
Rigo M, Reiter CH, Weiss H-R: Effect of conservative management on the prevalence of surgery in patients with adolescent idiopathic scoliosis. Pediatr Rehabil. 2003, 6: 209-214. 10.1080/13638490310001642054.
Weiss H-R, Weiss G, Schaar H-J: Incidence of surgery in conservatively treated patients with scoliosis. Pediatr Rehabil. 2003, 6: 111-118. 10.1080/13638490310001593446.
Hibbs RA: An operation for progressive spinal deformity. NY Med J. 1911, 3: 1013-1016.
Shands AR, Barr JS, Colonna PC, Noall L: End-result study of the treatment of idiopathic scoliosis: Report of the Research Committee of the American Orthopaedic Association. J Bone Joint Surg Am. 1941, 22: 963-977.
Harrington PR: Treatment of Scoliosis. Correction and internal fixation by spine instrumentation. J Bone Joint Surg Am. 1962, 44: 591-611.
Tambornino JM, Armbrust EN, Moe JH: Harrington Instrumentation in correction of scoliosis: A comparison with cast correction. J Bone Joint Surg Am. 1964, 46: 78-88.
Doody MM, Lonstein JE, Stovall M, Hacker DG, Luckyanov N, Land CE: CE for the U.S. Scoliosis Cohort Study Collaborators: Breast cancer mortality after diagnostic radiography: Findings from the U.S. Scoliosis Cohort study. Spine. 2000, 25: 2052-2063. 10.1097/00007632-200008150-00009.
Sponsellor PD, Cohen MS, Nachemson AL, Hall JE, Wohl MB: Results of surgical treatment of adults with idiopathic scoliosis. J Bone Joint Surg Am. 1987, 69: 667-675.
MacEwen GD, Bunnell WP, Sriram K: Acute neurological complications in the treatment of scoliosis. J Bone Joint Surg Am. 1975, 57: 404-408.
Coe JD, Arlet V, Donaldson W, Berven S, Hanson DS, Mudiyam R, Perra JH, Shaffrey CI: Complications in spinal fusion for adolescent idiopathic scoliosis in the new millennium. A report of the Scoliosis Research Society morbidity and mortality committee. Spine. 2006, 31: 345-349. 10.1097/01.brs.0000197188.76369.13.
Danielsson AJ, Nachemson AL: Radiological findings and curve progression 22 years after treatment for adolescent idiopathic scoliosis: Comparison of brace and surgical treatment with a matching control group of straight individuals. Spine. 2001, 26: 516-525. 10.1097/00007632-200103010-00015.
Danielsson AJ, Nachemson AL: Childbearing, curve progression, and sexual function in women 22 years after treatment for adolescent idiopathic scoliosis. A case-control study. Spine. 2001, 26: 1449-1456. 10.1097/00007632-200107010-00015.
Danielsson A, Wiklund I, Pehrsson K, Nachemson A: Health-related quality of life in patients with adolescent idiopathic scoliosis: A matched follow up at least 20 years after treatment with brace or surgery. Euro Spine J. 2001, 10: 278-288. 10.1007/s005860100309.
Dickson JH, Erwin WD, Rossi D: Harrington Instrumentation and Arthrodesis for Idiopathic Scoliosis: A twenty-one year follow-up. J Bone Joint Surg Am. 1990, 72: 678-683.
Helenius I, Remes V, Yrjönen T, Ylikoski M, Schlenzka D, Helenius M, Poussa M: Comparison of long-term functional and radiologic outcomes after Harrington instrumentation and spondylodesis in adolescent idiopathic scoliosis: A review of 78 patients. Spine. 2002, 27: 176-180. 10.1097/00007632-200201150-00010.
Mariconda M, Galasso O, Barca P, Milano C: Minimum 20-year follow-up results of Harrington rod fusion for idiopathic scoliosis. Eur Spine J. 2005, 14: 854-861. 10.1007/s00586-004-0853-7.
Connolly PJ, Von Schroeder HP, Johnson GE, Kostuik JP: Adolescent idiopathic scoliosis: Long-term effect of instrumentation extending to the lumbar spine. J Bone Joint Surg Am. 1995, 77: 1210-1216.
Götze C, Liljenqvist UR, Slomka A, Götze HG, Steinbeck J: Quality of life and back pain: Outcome 16.7 years after Harrington instrumentation. Spine. 2002, 27: 1456-1464. 10.1097/00007632-200207010-00016.
Helenius I, Remes V, Yrjönen T, Ylikoski M, Schlenzka D, Helenius M, Poussa M: Harrington and Cotrel-Dubousset instrumentation in adolescent idiopathic scoliosis: Long-term functional and radiographic outcomes. J Bone Joint Surg Am. 2003, 86: 2303-2309.
Luk KDK, Lee FB, Leong JCY, Hsu LCS: The effect on the lumbosacral spine of long spinal fusion for idiopathic scoliosis: A minimum 10-year follow-up. Spine. 1987, 12: 996-1000.
Pérez-Grueso FS, Fernández-Baíllo N, Arauz de Robles S, Fernández AG: The low lumbar spine below Cotrel-Dubousset instrumentation: Long-term findings. Spine. 2000, 25: 2333-2341. 10.1097/00007632-200009150-00011.
Dickson JH, Mirkovic S, Noble PC, Nalty T, Erwin W: Results of operative treatment of idiopathic scoliosis in adults. J Bone Joint Surg Am. 1995, 77A: 513-523.
Hayes MA, Tompkins SF, Herndon WA, Gruel CR, Kopta JA, Howard TC: Clinical and radiological evaluation of lumbosacral motion below fusion levels in idiopathic scoliosis. Spine. 1988, 13: 1161-1167.
Islam NC, Wood KB, Transfeldt EE, Winter RB, Denis F, Lonstein JE, Ogilvie JW: Extension of fusions to the pelvis in idiopathic scoliosis. Spine. 2001, 26: 166-173. 10.1097/00007632-200101150-00011.
Noonan KJ, Dolan LA, Jacobson WC, Weinstein SL: Long-term psychosocial characteristics of patients treated for idiopathic scoliosis. J Pediatr Orthop. 1997, 17: 712-717. 10.1097/00004694-199711000-00004.
The authors wish to thank Terry Orrick for her assistance in the completion of this manuscript.
This is an extensively revised version of a book chapter published as Asher M, Burton DC: Natürlicher verlauf und langzeitauswirkungen der idiopathischen adoleszentenskoliose. In Wirbel Säulen Deformitäten: Konservatives Management. Edited by Weiss HR. München: Pflaum; 2003:97–107.
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Asher, M.A., Burton, D.C. Adolescent idiopathic scoliosis: natural history and long term treatment effects. Scoliosis 1, 2 (2006). https://doi.org/10.1186/1748-7161-1-2
- Adolescent Idiopathic Scoliosis
- Idiopathic Scoliosis
- Adolescent Idiopathic Scoliosis Patient
- Thoracic Curve
- Proximal Junctional Kyphosis