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The Sforzesco brace can replace cast in the correction of adolescent idiopathic scoliosis: A controlled prospective cohort study
© Negrini et al; licensee BioMed Central Ltd. 2008
Received: 08 September 2008
Accepted: 31 October 2008
Published: 31 October 2008
The conservative treatment of adolescent idiopathic scoliosis (AIS) has traditionally been divided into two phases–correction and stabilisation–and casts, even if less used today, can be considered the best standard in the correction phase. Till the present, however, no comparison between cast and brace efficacy has been proposed.
This is a prospective cohort study with a retrospective control group. The aim was to verify if it is possible to obtain with a specifically developed rigid brace results comparable to a cast. We considered fifty AIS patients who had refused surgery, aged 14.1 ± 1.5 years, with 46.7 ± 7.8° Cobb scoliosis. Thirty-two consecutive patients (with no drop-outs) were prospectively followed up with the Sforzesco brace (SBG), and compared against a retrospective group of eighteen patients treated with the Risser cast (RCG). The treatment time (the total correction phase) was 19 ± 3 months. Out-of-brace x-rays were compared, as well as clinical results.
Compliance and hours of treatment were higher in the RCG while all the other parameters were not different. We observed a reduction of 6° Cobb and an important aesthetic gain in both groups (P<0.05). Three patients (6%) worsened, while 56% improved (36% at least 10°, and 14% 15° or more). The SBG did show results comparable to the RCG, with only minor differences in terms of scoliosis correction. On the contrary, straightening of the spine (decrease of the sagittal physiological curves) was much higher in the RCG but was not clinically significant in the SBG.
In the corrective phase of AIS treatment it is possible with a specific rigid brace (Sforzesco – SPoRT concept) to obtain scoliosis correction similar to cast. Due to the human and social costs of casting, and worst sagittal profile results, Sforzesco brace should be the preferred method wherever possible.
Recently a new brace has been proposed–the Sforzesco brace–whose efficacy in the short term has been shown in comparison with the Lyon brace [17, 18]. This orthosis has been developed with the potential goal of substituting casts in the correction phase of AIS treatment. Nevertheless, in our perspective not using a treatment of high efficacy (cast) that we used until now [7, 8, 13], possibly eliminating an important instrument against high-degree AIS and increasing the rate of surgery, only because of comfort for the patient and ease for the physician, definitely required a scientific proof. Our clinical aim was to decide if abolishing Risser cast treatment was possible thank to the Sforzesco brace, or if we had to go back to casting AIS as we used to do until 2004.
The objective of this paper is to present the results obtained through our comparison of all the first patients we treated with the Sforzesco brace against those we previously had with the Risser cast in the corrective first phase of AIS treatment.
This is a prospective cohort study with a retrospective control group. It is a best clinical practice study, because both therapies compared were considered by the treating physicians and teams (which was the same for all patients) as the best possible treatments for their patients at the time in which they had been applied. The length of follow-up for this study was the entire period of the correction phase.
We included fifty AIS patients (forty females, ten males), mean age 14.1 ± 1.5 years; the Risser sign (RS) median was 2 (distribution was RS 0: 15; RS 1: 7; RS 2: 6; RS 3: 10; RS between 3 and 4 – different on the two sides: 12); thirty-six females were post-menarche since 1.6 ± 1.1 years: in a preliminary study we verified that in Italy menarche appears very early and it's not a reliable sign of maturity, therefore we do not consider this parameter as a reason not to treat patients and we rely only on skeletal signs; average weight was 52.8 ± 10.3 kg, height 161.4 ± 7.8 cm. All patients were at their first evaluation at our institute and were at high risk of surgery (or had already refused it), and this treatment was considered the last chance in order to avoid fusion. In fact, 40% had been already treated with other orthosis but worsened. All patients with curves over 50° Cobb were first sent to surgical evaluation, and were treated only if surgery was firmly refused by the patient and his/her family, after informed consent and careful explanations of possible drawbacks of their choice (possible drawbacks of conservative treatment relate to its failure and include the prolonged use of brace without result, and a reduced surgical correction due to acquired rigidity). In all evaluations of these patients during treatment the surgical option was discussed.
The average deformity was 46.7 ± 7.8° Cobb, with an ATR (Angle of Trunk Rotation) of 12.9 ± 4.5° and corresponding hump height of 19.1 ± 6.7 mm. The Aesthetic Index  was 4.6 ± 1.3 on a six-point scale. The patients were divided into two groups, according to the treatments they had received. One group (SBG) included all the first thirty-two consecutive patients (twenty-five females, seven males), recruited between January 2004 and January 2006, and prospectively followed up with the Sforzesco brace; the second group (RCG) included all eighteen patients (fifteen females and three males) treated with the Risser cast we had retrieved in our database. They started their treatment between January 1998 and July 2003. Further analyses have been performed considering two sub-groups defined according to the bone age: Risser sign 2 or less (R2), versus Risser sign 3 or more (R3).
The Risser cast
SPoRT concept: the Sforzesco Brace
All patients in both group performed exercises and consequently we had two sub-groups: SEAS exercises [22, 23] and usual physiotherapy. The patients decided by themselves whether they preferred to be treated according to our protocol of exercises (SEAS) or by a rehabilitation center or single physiotherapist of their choice (Usual Physiotherapy).
The main goals of SEAS (Scientific Exercises Approach to Scoliosis) in case of bracing full-time are: elimination or reduction of side effects caused by immobility (muscular hypotrophy), or the brace itself (reduction of sagittal curves, mainly kyphosis, and breathing impairment) and accentuation of brace corrective pushes [13, 24, 25]. Such goals are pursued through specific therapeutic modalities, subdivided into treatment phases: we describe here only those used in this study. Preparation for bracing : We request the execution of exercises aimed at increasing the range of motion of the spine on all planes, so as to allow the brace to exert the maximum possible correction. We also continue proposing mobilisation exercises in the first phase of brace wearing, when it is worn for at least 21 hours per day. Brace wearing period: We initially propose exercises of "wriggling out of supports" by using the upper and lower limbs so as to facilitate adaptation to brace usage for the recommended number of hours. We require the execution of: modelling exercises in order to increase brace pressure on humps ; muscular endurance strengthening exercises, requiring lumbar lordosis and thoracic kyphosis preservation, while frontal and cross-sectional plane correction is guaranteed by brace pushes. We propose specific breathing activation exercises only when we detect some significant reductions of vital capacity.
The Usual Physiotherapy participants performed many different exercise protocols at a local facility according to what was preferred by their single therapist: In most cases these were in a group context, while in all cases they lasted forty-five to ninety minutes and were performed two or three times per week as in the SEAS sub-group. In some cases, the patients were required to repeat their exercises daily at home.
In the sagittal plane, the distance from the plumbline (tangent to the apex of thoracic kyphosis) has been measured in cm at the C7 (C7P) and L3 (L3P) vertebrae; the Sagittal Index (SI) had been computed as the average of the two distances; and the intra-examiner repeatability is 0.9 cm for C7P and 1.2 cm for L3P . Consequently, a difference of 1 cm for C7P, and 1.5 cm for L3P and SI, was considered a significant variation;
The Aesthetic Index , which is the sum of three items (shoulders, scapulae and waist symmetry) evaluated on a three-point (0-1-2) scale to give a total of six points, was evaluated in terms of repeatability , and accordingly variations were considered if there was a change of at least two points.
The actual hours per day of bracing;
The total hours of bracing during all treatment (calculated in days);
The compliance, calculated as the percentage hours per day of bracing versus what was prescribed.
These measurements were much more accurate for RCG, where a cast had to be worn all day long consecutively without any possibility of removing it, for nearly twelve months in the first period of treatment.
All patients were evaluated always by the same treating physician. We performed reliability studies of all measurements performed: most have been previously reported [19, 38, 40], while Cobb degrees intra-observer reliability ranged between 2° and 4° Cobb according to the physician considered .
Statistical analysis was performed, after evaluation of the distribution of variables, through ANOVA and t-test (paired for in-group comparisons, and unpaired between groups), Mann-Whitney, Fisher's Exact and chi-square tests. The statistical significance was set with α = 0.05.
We found no significant differences between the two groups at the start of treatment in all clinical and radiographic parameters nor in the total duration of treatment (19 months both groups), while, as expected, the amount of brace wearing was statistically different: 522 ± 159 versus 428 ± 126 (-10%) days in total, and 22.3 ± 2.4 versus 20.1 ± 3.7 (-18%) hours per day at the final evaluation in RCG and SBG, respectively. Moreover, the difference in compliance was significant: 99.0 ± 3.4% versus 89.3 ± 8.5 respectively. In the "corrective phase" considered we did not have any drop-out, while a compliance rate lower than 80% was reported by 4 patients, all in the SBG (12.5%).
Comparing the two groups (See additional file 2), the only differences were in the thoracic ATR, in C7P and SI, which were all reduced more in RCG than in SBG. Looking at results in single patients (See additional file 3), only two patients in SBG and one in RCG worsened (6% in total) by 7°, 8° and 10° respectively, while more than 50% improved by 6° or more, mainly in SBG. Particularly, the best results have been obtained in the most severe curve of each single patient: 36% (six in RCG and twelve in SBG) improved at least 10°, while 14% (two in RCG and five in SBG) improved at least 15°. The clinical results were better than the radiographic results, specifically in terms of aesthetics, even if the side effect of sagittal straightening of the spine was quite common, particularly in RCG (being statistically significant for SI), but also in SBG at around 50% of cases. The thoracic reduction of ATR was confirmed to be higher in RCG than SBG.
In the RCG 7 patients are still in treatment, 1 went to surgery and 1 dropped out; in the SBG we had no surgical patients yet, but 2 dropped-out.
Looking at the influence of skeletal maturity (Risser test) on results, we did not find any difference according to the bone age of the patient (See additional file 4), nor to pre-menarchial and post-menarchial status. Conversely, we verified that the patients treated with SEAS exercises statistically had significantly better clinical results than the usual physiotherapy in terms of ATR (a decrease of 6° in SEAS versus 3.5° in usual physiotherapy) and hump (-9.7 mm in SEAS versus -5.0).
The results of this study show the efficacy, in the correction phase, of the Risser cast and the Sforzesco brace. Only three patients (6%), out of a series of fifty with an average of 47° Cobb curves, worsened during a period of eighteen months of maximal effort of correction, while more than 50% reduced their maximal curve by at least 6° (and 14% by 15° or more). The Sforzesco brace did show results comparable to the Risser cast, having only minor differences in terms of scoliosis correction but major differences in terms of the reduction of specific spinal side effects. In fact, even if the sagittal parameters were reduced in both braces, the straightening of the spine was much higher (threefold for C7 and twofold for L3) in RCG, while it was not clinically significant in SBG.
The reduction of thoracic ATR and rib hump is higher in RCG than in SBG;
The flattening of the spine is higher in RCG than in SBG;
The thoracic curve reduction is higher in SBG than in RCG.
The above data clearly suggests that the correction action of the Risser cast is too posterior while the SPoRT concept [17, 18] of the Sforzesco brace is better balanced, since it serves to reduce the side effects while giving raise to better frontal-plane results with nevertheless good aesthetic ones (rib hump and Aesthetic Index).
The fact that thoraco-lumbar curves, as well as ATR and hump, have been better corrected in RCG than SBG should be carefully considered in the future, because this could suggest a possible subgroup of patients in which the mechanism of action of the Risser cast is more suitable than the SPoRT concept. Moreover, as a secondary result, in this study we confirmed what we had previously found regarding the higher efficacy of SEAS exercises versus the usual physiotherapy [26, 42].
Interestingly, splitting the results according to maturation parameters did not show any difference between the sub-groups (See additional file 4). A possible explanation of this unexpected result is that our data relate only to the correction phase, and that few patients are considered. Nevertheless, we do really lack more data on this respect, and future papers should carefully look at this point.
One question could be if the results of the "correction phase" remain with time and if these patients go to surgery or not. Provisionally, we can say today that 1 out of the 18 patients in the RCG went to surgery, while 1 dropped out. These results can be explained with a selection bias: in fact many of these patients already decided not to go to surgery before starting treatment. Another explanation could be that, until now, no patient in RCG worsened, while 67% improved of 5° or more: the average result at this point of treatment is a reduction of the worst curves of 7.8 ± 7.5° Cobb, with no difference according to bone age nor to treatment finished or not; 3 patients, still in treatment, have more than 50° Cobb curves (5 at start of treatment).
In the SBG, we have until now 2 drop-outs, that in a worst-case analysis should be considered as failures, while all the other patients are still in treatment and did not went to surgery (today 5 patients are over 50° Cobb versus 9 at start of treatment). The average result at this point of treatment is a reduction of the worst curves of 7.5 ± 7.5° Cobb, with a rate of improvement of 72% and of worsening of 9%: in SBG the rate of worsening is higher in R2 group (16%). These results must be considered totally provisional because patients are still in treatment, even if we will analyze them thoroughly in future studies.
Compliance to bracing is considered a key issue today [43, 44], even if measuring systems are still research tools [45–49] and not yet ready for everyday clinical usage, as should be needed in a study like this. Moreover, the RCG was a retrospective group and was therefore treated some years ago. Anyway, we must consider that in the RCG we inevitably had the highest compliance (99%) because for nearly twelve out of eighteen months of treatment the patients could not physically avoid wearing their casts, and after that the motivation is usually very high. The declared compliance obviously was not the same in the SBG (-10%), where we found all the 4 bad compliers: at any rate this was the new treatment, in which we also had fewer total hours of therapy due to the medical prescription and characteristics of a brace versus a cast. Because the compliance with the brace is really not known without some type of monitor, it is possible that the real compliance versus what was declared by the patients was much less, as has recently been shown , but this could have been an influence on the RCG for six months and on the SBG throughout the entire study. Nevertheless, the results for the two groups were totally comparable, and this gives even more strength to what was achieved in the SBG.
We are aware of very few studies in the indexed literature that compare the results of different concepts of bracing: These have shown the superiority of Boston over Charleston , TLSO over Milwaukee and Charleston , Chêneau over SpineCor , and the similarity of Milwaukee and Boston with a metal over-structure . All these studies related to patients with average Cobb angles of less than 35°. We recently proved the short-term superiority of the Sforzesco brace (SPoRT concept) over the Lyon (three-point concept) in a group of patients refusing fusion, with very-high-degree scoliosis (45 ± 7° for worst individual curves, 40 ± 10° for all curves) . To our knowledge, this is the first study to compare the efficacy of a brace versus a cast for AIS correction.
The main advantages of this study include the prospective data collection in the SBG, where all treated patients have been included. The fact that we have used a best clinical practice approach, because both treatments were as of that time considered the best possible ones by the treating team (an assessment that did not change during the study), along with the fact that we used a complete team approach, including treatment through [9, 54]. On the other hand, limitations include: the retrospective collection of data in RCG, but this is the only way to have a best clinical approach; not having included the dropouts, but this was not possible in the retrospective RCG, so that the study could not include an intent-to-treat analysis; the absence of data on reducibility of the curves through lateral bending radiographs, avoided in patients not surgically treated; and the fact of being focused only on the corrective phase (i.e., short-term results). In this regard we must consider that research in the field of bracing cannot be limited only to final results, otherwise we will have no possibility of understanding where we might possibly fail or where we have to focus in order to increase our knowledge and ability to treat patients. Obviously these results are not the final ones, but the corrective phase of AIS treatment is the starting one; and presumably the better the results of this phase, the better the final ones . The objective of this paper was not to prove the efficacy of bracing or casting but to verify whether the Sforzesco brace could be considered a valid option to substitute the Risser cast in this corrective phase of AIS treatment.
Today it is possible to substitute the Risser cast in the corrective phase of AIS treatment with a specific rigid brace (Sforzesco brace), as developed according to the SPoRT concept. Future research should focus on which patient could benefit more from one instrument versus the other, because sub-grouping has provided some clues to the possible differences. Anyway, due to the human and social costs of casting, bracing should always be the preferred treatment method.
Written informed consent was obtained from the patient for publication of this case report and accompanying images.
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