- Research
- Open Access
Early weaning in idiopathic scoliosis
- Harald Steen1Email authorView ORCID ID profile,
- Johan Emil Lange2 and
- Jens Ivar Brox3
- Received: 13 August 2015
- Accepted: 29 October 2015
- Published: 19 November 2015
Abstract
Background
Many years of bracing represent a burden to the patients. Early weaning may be the result of poor compliance, but may also be planned in patients with a long expected treatment time and a reduced stable primary curve during bracing. The aim of the present cohort study was to compare curve size, health related quality of life and surgical rates at long-term follow-up after ordinary bracing, planned and unplanned early weaning.
Methods
Three hundred eighty-one patients (353 girls/28 boys) with late-onset juvenile (n = 30) and adolescent (n = 351) idiopathic scoliosis and a mean primary major curve of 33.1 (range 20–57)° were treated with Boston brace and followed prospectively.
Results
Ordinary brace treatment was completed in 290 (76 %) patients, planned early weaning at bone age <14 years in 59 (16 %), and unplanned early weaning in 32 (8 %), while 14 (5 %), 1 (2 %), and 12 (38 %) had surgery, respectively. Forty-eight (81 %) of the patients had a primary curve ≤ 25° at planned early weaning. Six-teen (27 %) of those who had planned early weaning, resumed bracing after a mean time of 2.0 years. The mean curve size at long-term follow-up in average 23.4 years after weaning, was smaller (p < 0.001) in patients with planned early weaning (25.1°) compared with ordinary bracing (34.0°) and unplanned early weaning (34.8°). Patient satisfaction and self-image at long-term was better in the planned early weaning group (p < 0.05), but differences were small.
Conclusion
The benefit of planned early weaning was the shortened bracing time and good clinical results. This procedure may be attempted if curve reduction is stable over time and the primary curve is 25° or less in patients with several years of expected bracing. The patients should be monitored carefully and regularly at 4-6 months intervals until maturity, and a new brace should be prepared if the curve increases significantly.
Keywords
- Idiopathic scoliosis
- Scoliosis treatment
- Brace weaning
- Curve progression
Background
A Cochrane review concluded that there is very low quality evidence in favour of using braces for adolescent idiopathic scoliosis [1]. Later a recently published randomised controlled trial (BRAIST study) found that brace treatment is effective in reducing the number of patients who progress to 50° [2]. The rate of success was 72 % after bracing compared with 48 % after observation. A number of patients used the brace less than planned and the benefit of bracing increased with longer hours of brace wear. Results are in agreement with previously published cohort studies with >19 years follow-up [3–6]. We reported that the surgical rate increased with poor compliance and aborted brace wear [7]. In a subgroup of these patients early weaning was planned and we have not previously reported the results of this strategy. The aim of the present study was therefore to evaluate progression of the scoliotic curve and the surgical rate in patients with unplanned early weaning (aborted brace wear), planned early weaning and ordinary brace wear until maturity.
Methods
Three hundred eighty-one patients (353 girls and 28 boys) with Boston brace treatment for idiopathic scoliosis were included and followed prospectively [7]. The reason for bracing was adolescent idiopathic scoliosis (AIS) discovered at 10 years of age or older [8] in 351 patients, and late-onset juvenile idiopathic scoliosis at 7 to 9 years in 30 patients. The mean primary major curve measured 33.1 (range 20–57)°. The indication for bracing was a major scoliotic curve ≥ 20° with an observed progression >5° after 4 months and Risser sign <3. Patients had follow-ups with clinical and radiological examination at 4-6 months intervals throughout the brace treatment period. Wearing of the brace was assessed by one of the authors (orthopaedic scoliosis surgeon JEL) and reported as: ordinary as prescribed, irregular, or aborted. Patients were recommended to use the brace for 23 h daily. Wearing of the brace <20 h daily was described as irregular. Initially bracing was planned until maturity (Risser 5 in boys or Risser 4 or two years after menarche in girls). Because some of the patients started bracing at a young age with a long time treatment perspective, the original plan was changed and the idea of planned early weaning to shorten the years of brace wear was concepted and realized 35 years ago by the senior author (JEL). He started early weaning in patients before reaching puberty after 2–3 years or more of brace treatment. These patients demonstrated a good effect of the brace with a stable reduction of the primary curve to 25° or less at repeated measurements. Later, influenced by the positive results associated with this new regimen, he also included a few patients with less than 2 years of brace wear. All had skeletal age <14 and Risser 3 or lower at planned early weaning. The weaning procedure was performed during a period of 2–3 months by 2 h less bracing time every week and the curve was controlled after 4 months. Patients with early weaning were followed at regular intervals of 4–6 months until skeletal maturity. After weaning patients with ordinary brace treatment time had follow-ups at 6, 12, and 24 months. After several years a long time follow-up was accomplished in all the patients.
Radiology
Prior to bracing standing radiographs were taken in the front and lateral projections. In addition non-weight bearing (flexibility) frontal radiographs were exposed in the prone position, and after brace fit standing (redressment) radiographs with the brace on were taken. Radiological measurements were performed by an orthopedic surgeon (JEL) and controlled by an experienced radiologist. Both used the Cobb method manually. Digital measurements were used at long-term follow-up. The intra-observer error for the Cobb angle was about 3° in a relatively recent study using manual and digital measurements, and <5° in a previous study [9, 10]. In the present study the measurement error was within these limits as evaluated by the reproducibility of radiographic readings of repeated measurements of all radiographs from 10 patients at regular intervals. In patients with double thoracolumbar curves the largest curve prior to bracing was defined as the major curve.
Surgery
Surgery was recommended in patients with curve progression to >45° during bracing and at weaning. At later follow-up patients with major curves <50° were not recommended surgery. Information about surgery was recorded in a standardised form and obtained from a long-term questionnaire and checked in the medical journals.
Questionnaires
At long-term follow-up, a standardised questionnaire was filled in by the patients. The questionnaire comprised validated measures of pain, disability, quality of life and work, comorbidity, surgery, and questions about demographics.
A validated Norwegian version of the Scoliosis Research Society 22 questionnaire (SRS-22) was used for evaluation of health related quality of life [11]. The SRS-22 covers four domains (function/activity, pain, self-perceived image, mental health) each with 5 questions, and one domain (satisfaction with treatment) with 2 questions. Each item has 5 verbal response alternatives ranging from 1 (worst) to 5 (best). Results are expressed as the mean (total sum of the domain divided by the number of items answered) for each domain.
Patients rated their overall function by the Global Back Disability Question [12]. This is a single question designed to measure the patients’ overall rating of their back disability today. There were five response alternatives: “excellent, none or unimportant complaints", “good, occasionally bothered by back pain", “fair, some back pain and limited function", “poor, unchanged, considerable complaints and severe disability", and “miserable, worse, not self-reliant in activities of daily living”.
A Norwegian version of the original Oswestry Disability Index (version 1.0) was used to evaluate back-specific disability [12]. The sum of 10 questions is calculated and presented as a percentage, wherein 0 % represents no pain and disability, and 100 % represents the worst pain and disability.
The General Function Score was used to measure disability in activities of daily living [13]. Patients answered nine questions using one of three alternatives: “can perform”, “can perform with difficulty due to back complaints”, and “cannot perform due to back complaints”. The score was presented as a percentage wherein 100 % represents maximum disability.
EuroQol is a generic (non-disease specific) questionnaire for measurement of health related quality of life and includes five items regarding quality of daily life, covering the domains of mobility, self-care, usual activities, pain and discomfort, and anxiety and depression (EQ-5D) and a visual analogue score (EQ-VAS) for assessment of overall current health [14, 15].
Statistical analysis
Results are presented as means and range or standard deviation, or as percentages. The normal distribution of baseline, follow-up data, and differences were checked by histograms and by the Shapiro-Wilk test. In sample cases of non-normal distribution non-parametric methods were used. A General Linear Model One-way analysis of variance was applied to test differences between the 3 subgroups in continuous variables at baseline, weaning, and follow-up: 1) patients with unplanned early weaning, 2) planned early weaning, and 3) ordinary brace wear until maturity. In a previous study we classified irregular wear and unplanned early weaning as poor compliance [7]. In the present study we classified patients with irregular wear as ordinary bracing unless bracing was aborted. With the assumption of unequal variances in unequally sized groups, Dunnett’s T3 was used for post hoc multiple comparisons. Chi-square analyses were applied for testing of categorical variables and Kendall’s Tau-b measure of association for multiple nominal variables. Statistical evaluation was performed by use of the Statistical Analysis System (SAS version 9.2; Cary, NC) and by SPSS software, version 21.0 (SPSS Inc., Chicago).
Consent
The committee for medical research ethics in the health Region South-East in Norway and the institutional review board (hospital’s patient ombudsman) approved the study (REK 2010-3677). Written informed consent was obtained from the participating patients.
Results
Ordinary brace treatment was completed in 290 (76 %), while 14 (5 %) of these patients were operated due to curve progression in spite of brace treatment. Early weaning was planned in 59 patients, 16 (27 %) of these started a new period of brace treatment and 1 (2 %) was operated. Early weaning was unplanned in 32 patients, mainly due to pain, psychological distress or skin problems. Among these patients, bracing was resumed in 6 (19 %), and 12 (38 %) were operated. The surgical rate was significantly different in patients with ordinary bracing, planned and unplanned early weaning (p < 0.005; Kendall’s Tau-b).
Major curves at baseline
Baseline characteristics in 381 Boston braced patients
Characteristic | A. Unplanned early weaning | B. Planned early weaning | C. Ordinary bracing |
|---|---|---|---|
n = 32 | n = 59 | n = 290 | |
Age at start brace treatment (years) | 11.5 (7.7–15.5) | 11.4 (7.5–16.0) | 13.7 (6.9–17.1)a |
Bone age at start brace treatment (years) | 10.8 (7–14) | 10.4 (5–13) | 13.2 (7–16)a |
Bone – Chronological age difference at start brace treatment (years) | −0.8 (−2.7–0.8) | −1.0 (−4.0–2.0)b | −0.5 (−3.2–2.1) |
Age at menarche (years) | 13.6 (11–16) | 13.7 (11–16) | 13.4 (7–19) |
(n = 25) | (n = 51) | (n = 262) | |
Major curve standing without brace at start of treatment (°) | 34.3 (20–56) | 29.8 (21–52)c | 33.6 (20–57) |
Major curve prone without brace at start of treatment (°) | 24.3 (8–41) | 19.1 (7–42)d | 23.7 (9–45) |
Major curve standing in brace (°) at start of treatment | 15.7 (4–37) | 11.3 (1–37)c | 17.4 (1–44) |
Major curve flexibility (°) | 10.0 (1–22) | 10.7 (2–23) | 9.9 (−2–24) |
Major curve flexibility (%) | 29.1 (5–73) | 36.1 (7–70)e | 29.6 (−5–69) |
Major curve redressment (°) | 18.7 (1–46) | 18.6 (8–33) | 16.2 (3–35)f |
Major curve redressment (%) | 53.7 (4–86) | 62.9 (25–97)e | 48.9 (7–96) |
Overall primary scoliotic curve development in 381 Boston braced patients with late-onset juvenile or adolescent idiopathic scoliosis. Patients with resumed bracing and operated patients included
Major curves at weaning and long - term follow-up
Results at weaning and last follow-up control in 381 Boston braced patients
Characteristic | A. Unplanned early weaning | B. Planned early weaning | C. Ordinary bracing |
|---|---|---|---|
n = 32 | n = 59 | n = 290 | |
Age at weaning (years) | 14.3 (9.6–16.6) | 14.9 (11.0–18.9)a | 16.3 (12.4–19.8)b |
Bone age at weaning (years) | 13.6 (9–15) | 13.9 (11–16) | 15.8 (11–18)b |
Bone – Chronological age difference at stop brace treatment (years) | −0.7 (−3.6–2.1) | −1.0 (−4.0–2.0)c | −0.4 (−3.2–2.5) |
Time in brace at weaning (months) | 31.9 (6–82) | 36.4 (12–71)d | 31.1 (6–113) |
Number of patients in brace time subgroups (months) <24 / ≥24 and <36 / ≥36 and <48/≥48 | 16/7/1/8 | 16/18/12/13 | 91/117/56/26 |
Major curve standing at weaning (°) | 35.0 (6–58) | 20.6 (1–45)e | 29.3 (6–58)f |
Time to last follow-up after weaning (years) | 24.2 (2.7–30.4) | 23.1 (15.0–30.7) | 23.4 (2.4–32.1) |
Major curve standing at last follow-up (°) | 34.8 (13–62) | 25.1 (9–54)e | 34.0 (7–81) |
Major curve difference at last follow-up relative to start bracing (°) | 0.5 (−23–21) | −4.7 (−28–23)a | 0.5 (−22–51) |
Number (%) operatedg | 12 (38) | 1 (2) | 14 (5) |
The patients who resumed bracing saved a mean time of 2.0 (0.4–3.9) years in the brace, while the average total time bracing was 36.4 months and significantly (p < 0.05) longer in the planned early weaning group compared to the patients with ordinary bracing (31.1 months).
At weaning the standing major curve without brace in the patients with planned early weaning was in average 20.6° compared with 29.3° in the ordinary bracing group, and 35.0° in the patients with unplanned early weaning.
At the last long-term follow-up control the final average standing major curve with operated patients included was in average 25.1° and signficantly less in the planned early weaning group compared to the unplanned (34.8°) and ordinary bracing (34.0°) groups, respectively. The change in the major curve from baseline was in average a significant reduction of 4.7 ° in the planned early weaning group, while it was 0.5° increased in the two other groups (Table 2).
Planned early weaning
Fortyeight (81 %) of the patients had a primary curve ≤ 25° at weaning.
Sixteen (27 %) of the patients resumed bracing. All these patients had initially a curve reduction >5°; the mean reduction was 14.8° (SD 6.1). The curve increased in average 15.4° (SD 3.7) during a mean time of 2 years before bracing was resumed.
Questionnaires
Sociodemographic characteristics in 381 Boston braced patients with late-onset juvenile or adolescent idiopathic scoliosis at mean follow-up of 23.4 years
Characteristic | A. Unplanned early weaning | B. Planned early weaning | C. Ordinary bracing |
|---|---|---|---|
n = 32 | n = 59 | n = 290 | |
Educational level | |||
Primary school (9 year) | 7 | 9 | 9 |
High school (12 year) | 32 | 19 | 22 |
University college | 61 | 72 | 69 |
Work status | |||
Working full time | 78 | 75 | 78 |
Working part-time | 4 | 7 | 7 |
Student/homemaker | 6 | 7 | 5 |
On sick leave | 0 | 3 | 2 |
Disability pension | 12 | 8 | 8 |
Changed job because of back pain or disability | 36 | 34 | 24 |
Scoliosis influenced my choice of education and job | 34 | 28 | 29 |
Comorbidity | 23 | 30 | 33 |
Smoking | 34 | 13 | 20 |
Any treatment last year | 52 | 59 | 56 |
Physiotherapy last year | 19 | 35 | 27 |
Born children (n =303) | 90 | 90 | 85 |
Pain in pregnancy (n = 303) | 46 | 49 | 53 |
Quality of life score results in 381 Boston braced patients with late-onset juvenile or adolescent idiopathic scoliosis at mean follow-up of 23.4 years
Outcome | A. Unplanned early weaning | B. Planned early weaning | C. Ordinary bracing |
|---|---|---|---|
n = 32 | n = 59 | n = 290 | |
Global Back Questiona | |||
Excellent | 5 | 20 | 79 |
Good | 18 | 23 | 131 |
Fair | 7 | 14 | 65 |
Poor | 2 | 2 | 14 |
General Function Score (0–100) | 9.7 (14.1) | 4.9 (7.8) | 7.0 (11.9) |
Oswestry Disability Index (0–100) | 12.1 (13.5) | 7.2 (9.9) | 8.4 (11.6) |
EQ – 5D (−0.5 to 1.0) | 0.75 (0.3) | 0.83 (0.2) | 0.82 (0.2) |
EQ – VAS (0–100) | 72.8 (18.9) | 79.1 (19.6) | 78.1 (17.4) |
SRS-22 (0–5) | |||
Pain | 4.0 (0.8) | 4.2 (0.8) | 4.1 (0.8) |
Physical function | 3.8 (0.8) | 4.1 (0.7) | 4.0 (0.7) |
Mental health | 4.0 (0.6) | 4.2 (0.7) | 4.1 (0.6) |
Self–image | 3.5 (0.8) | 4.0 (0.7)b | 3.7 (0.7) |
Satisfaction | 3.4 (0.9) | 4.0 (1.0)b | 3.7 (1.0) |
EQ-5D results in 381 Boston braced patients with late-onset juvenile or adolescent idiopathic scoliosis at mean follow-up of 23.4 years. Percentages are given
Discussion
The aim of the present study was to compare early planned brace weaning with ordinary bracing and unplanned early brace weaning. The benefit of planned early weaning in immature patients was the shortened bracing time and good clinical results. Patient satisfaction and curve size at long-term follow-up suggest that patient selection for the planned procedure was successful. Even with resumed treatment they saved in average 2 years of bracing. Only one patient was operated, while surgery was increased in the groups with ordinary weaning and unplanned early weaning.
The patients who had planned early weaning were younger at brace start, had smaller curves, and better curve flexibility and curve redressment in per cent. All these factors may have influenced outcome. Due to the young age and early start of brace treatment the total treatment time was longer in the planned early weaning patients compared to those with ordinary brace treatment, but still considerably reduced relative to the expected time until skeletal maturity. At brace weaning the average primary curve measured about 21°. The choice was therefore to continue bracing until maturity or to stop before maturity. Curve size and expected time in brace were strong arguments to stop bracing, but still the selected patient to receive early weaning was not mature and the choice of early weaning was against guidelines. In average bone age at stop bracing was 1.9 years lower compared with ordinary bracing.
The grouping of patients according to planned and unplanned bracing adds information to the previously published study [7] by reporting results in those with stable reduced or unchanged curves who had aborted brace wear as planned early weaning before skeletal maturity.
Quality of life was not reduced after bracing in a recently published trial on the effectiveness of bracing [2]. This suggests that the psychological burden of bracing is overestimated. Still patients would prefer not to use the brace if the risk of surgery and long-term quality of life are comparable.
The main limitation of the present study is lack of randomisation. In clinical studies in general and in this old clinical study in particular, stringent selection of patients is hard to accomplish. Even if the selection of patients for planned early weaning was not completely stringent, the majority (81 %) of the patients had a primary curve of 25° or less which is considered to be a threshold value for bracing.
Conclusions
We conclude that the benefit of planned early weaning was the shortened bracing time. It is our opinion that the procedure can be recommended in selected patients, in the present study they constituted 15 % of the patients braced. Planned early weaning may be attempted if curve reduction is stable and the primary curve is 25° or less in patients with several years of expected bracing. The patients should be monitored carefully and regularly at 4-6 months intervals until maturity, and a new brace should be prepared if the curve increases significantly. Ideally, this recommendation should be based on the findings from a future multi-center randomised study comparing planned early weaning and ordinary bracing in selected patients.
Declarations
Acknowledgements
The authors wish to acknowledge radiologist Ragnhild B Gunderson at the Radiological Department, Rikshospitalet, Oslo University Hospital, for performing measurements of the scoliotic curves. Are Hugo Pripp, statistician at Oslo Centre of Biostatistics and Epidemiology, Research Support Services, Oslo University Hospital is thanked for supervision and help. Sanyalak Niratisairak, Head Engineer at our Hospital’s Biomechanics Lab, is thanked for graphical help.
Funding
The study was supported by grants from the Foundation Sophies Minde Ortopedi AS.
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Authors’ Affiliations
References
- Negrini S, Minozzi S, Bettany-Saltikov J, Zaina F, Chockalingam N, Grivas TB, et al. Braces for idiopathic scoliosis in adolescents. Spine. 2010;35:1285–93.View ArticlePubMedGoogle Scholar
- Weinstein SL, Dolan LA, Wright JG, Dobbs MB. Effects of bracing in adolescents with idiopathic scoliosis. N Engl J Med. 2013;369:1512–21.View ArticlePubMedPubMed CentralGoogle Scholar
- Danielsson AJ, Nachemson AL. Radiologic findings and curve progression 22 years after treatment for adolescent idiopathic scoliosis: comparison of brace and surgical treatment with matching control group of straight individuals. Spine. 2001;26:516–25.View ArticlePubMedGoogle Scholar
- Danielsson AJ, Wiklund I, Pehrsson K, Nachemson AL. Health-related quality of life in patients with adolescent idiopathic scoliosis: a matched follow-up at least 20 years after treatment with brace or surgery. Eur Spine J. 2001;10:278–88.View ArticlePubMedPubMed CentralGoogle Scholar
- Lange JE, Steen H, Brox JI. Long-term results after Boston brace treatment in adolescent idiopathic scoliosis. Scoliosis. 2009;4:17.View ArticlePubMedPubMed CentralGoogle Scholar
- Lange JE, Steen H, Gunderson R, Brox JI. Long-term results after Boston brace treatment in late-onset juvenile and adolescent idiopathic scoliosis. Scoliosis. 2011;6:18.View ArticlePubMedPubMed CentralGoogle Scholar
- Brox JI, Lange JE, Gunderson R, Steen H. Good brace compliance reduced curve progression and surgery in patients with idiopathic scoliosis. Eur Spine J. 2012;21:1957–63.View ArticlePubMedPubMed CentralGoogle Scholar
- Weinstein SL, Dolan LA, Cheng JC, Danielsson A, Morcuende JA. Adolescent idiopathic scoliosis. Lancet. 2008;371:1527–37.View ArticlePubMedGoogle Scholar
- Kuklo TR, Potter BK, Schroeder TM, O’Brien MF. Comparison of manual and digital measurements in adolescent idiopathic scoliosis. Spine. 2006;31:1240–6.View ArticlePubMedGoogle Scholar
- Morrissy RT, Goldsmith GS, Hall EC, Kehl D, Cowie GH. Measurement of the Cobb angle on radiographs of patients who have scoliosis. Evaluation of intrinsic error. J Bone Joint Surg Am. 1990;72:320–7.PubMedGoogle Scholar
- Adobor R, Rimeslåtten S, Keller A, Brox JI. Repeatability, reliability, and concurrent validity of the SRS-22 and EuroQol in patients with adolescent Idiopathic scoliosis. Spine. 2010;35:206–9.View ArticlePubMedGoogle Scholar
- Holm I, Friis A, Storheim K, Brox JI. Measuring self-reported functional status and pain in patients with chronic low back pain by postal questionnaires. A reliability study. Spine. 2003;28:828–33.PubMedGoogle Scholar
- Hägg O, Fritzell P, Romberg K, Nordwall A. The general function score: a useful tool for measurement of physical disability. Validity and reliability. Eur Spine J. 2001;10:203–10.View ArticlePubMedPubMed CentralGoogle Scholar
- EuroQolGroup. EuroQol: A new facility for the measurement of health related quality of life. Health Policy. 1990;16:199–208.View ArticleGoogle Scholar
- Solberg TK, Olsen JA, Ingebrigtsen T, Hofoss D, Nygaard OP. Health-related quality of life assessment by the EuroQol-5D can provide cost-utility data in the field of low-back surgery. Eur Spine J. 2005;14:1000–7.View ArticlePubMedGoogle Scholar
